Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms α and β

Site-specific DNA cleavage by topoisomerase II (EC 5.99.1.3) is induced by many antitumour drugs. Although human cells express two genetically distinct topoisomerase II isoforms, thus far the role and determinants of drug-induced DNA cleavage have been examined only for a. Here we report the first h...

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Veröffentlicht in:	Biochemical pharmacology 1996-12, Vol.52 (11), p.1675-1685
Hauptverfasser:	Marsh, Katherine L., Willmore, Elaine, Tinelli, Stella, Cornarotti, Mariagrazia, Meczes, Emma L., Capranico, Giovanni, Fisher, L.Mark, Austin, Caroline A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amsacrine Amsacrine - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Chemotherapy DNA - metabolism DNA cleavage DNA Topoisomerases, Type II - chemistry human DNA topoisomerase IIα human DNA topoisomerase Ilβ Humans Isoenzymes - antagonists & inhibitors Medical sciences Molecular Sequence Data pBR322 Pharmacology. Drug treatments SV40 DNA Topoisomerase II Inhibitors
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