Tau protein after delta-9-tetrahydrocannabinol in a human neuroblastoma cell line

1. 1. A human neuroblastoma cell line, SH-SY5Y, was used to determine the effects of delta-9-tetrahydrocannabinol (THC) on microtubule-associated tau protein. 2. 2. After 48-hr treatment, THC (10 −9 M) decreased 50 kD tau protein in the cytoplasmic (supernatant) fraction, and in the membrane (pellet...

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Veröffentlicht in:	General Pharmacology 1996-10, Vol.27 (7), p.1141-1143
1. Verfasser:	Lew, G.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Brain Neoplasms - metabolism delta-9-tetrahydrocannabinol Depression, Chemical Dronabinol - pharmacology Drug addictions Electrophoresis, Polyacrylamide Gel Hallucinogens - pharmacology Humans Medical sciences Microtubules - metabolism neuroblastoma Neuroblastoma - metabolism Tau protein tau Proteins - biosynthesis Toxicology Tumor Cells, Cultured
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Zusammenfassung:	1. 1. A human neuroblastoma cell line, SH-SY5Y, was used to determine the effects of delta-9-tetrahydrocannabinol (THC) on microtubule-associated tau protein. 2. 2. After 48-hr treatment, THC (10 −9 M) decreased 50 kD tau protein in the cytoplasmic (supernatant) fraction, and in the membrane (pellet) fraction the drug (10 −7 M) also decreased 50 kD tau protein. 3. 3. This reduction in tau protein was accompanied by a 27% reduction ( P
ISSN:	0306-3623 1879-0011
DOI:	10.1016/0306-3623(95)02150-7