Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Vascular endothelial growth factor (VEGF), which acts via members of a family of endothelial-specific receptor tyrosine kinases, is the only factor that has been shown definitively to play a role in the formation of the embryonic vasculature. Only one other family of receptor tyrosine kinases, compr...

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Veröffentlicht in:	Cell 1996-12, Vol.87 (7), p.1171-1180
Hauptverfasser:	Suri, Chitra, Jones, Pamela F, Patan, Sybill, Bartunkova, Sona, Maisonpierre, Peter C, Davis, Samuel, Sato, Thomas N, Yancopoulos, George D
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-1 Animals Blood Vessels - embryology Endocardium - embryology Endothelial Growth Factors - physiology Endothelium, Vascular - cytology Endothelium, Vascular - embryology Gene Expression Regulation, Developmental Genes, Lethal Gestational Age Glycoproteins - physiology Heart - embryology Ligands Lymphokines - physiology Membrane Glycoproteins - physiology Mice Mice, Knockout Neovascularization, Physiologic Protein-Tyrosine Kinases - physiology Proteins - physiology Receptor, TIE-2 RNA, Messenger - genetics Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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