Antitumor Properties of Some 2-[(Dimethylamino)methyl]phenylgold(III) Complexes

Four analogues of the gold(III) complex [AuCl2(damp)] (1) (damp = 2-[(dimethylamino)methyl]phenyl) have been evaluated for antitumor activity. The compounds have structural features in common with cisplatin which was included as a comparison in the study. In vitro, against a panel of cell lines esta...

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Veröffentlicht in:	Journal of medicinal chemistry 1996-12, Vol.39 (26), p.5208-5214
Hauptverfasser:	Buckley, Robert G., Elsome, Amanda M., Fricker, Simon P., Henderson, Graham R., Theobald, Brian R. C., Parish, Richard V., Howe, Brian P., Kelland, Lloyd R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzylamines - chemistry Benzylamines - pharmacology Biological and medical sciences Cell Division - drug effects Drug Screening Assays, Antitumor Flow Cytometry General aspects Humans Magnetic Resonance Spectroscopy Medical sciences Mice Mice, Nude Neoplasm Transplantation Organogold Compounds Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Pharmacology. Drug treatments Tumor Cells, Cultured
Online-Zugang:	Volltext
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