Thermosensitive liposomes: Extravasation and release of contents in tumor microvascular networks

Purpose: The purpose of this study was to determine whether hyperthermic exposure would accelerate drug release from thermosensitive sterically stabilized liposomes and enhance their extravasation in tumor tissues. Materials and Methods: In vivo fluorescence video microscopy was used to measure the...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 1996-12, Vol.36 (5), p.1177-1187
Hauptverfasser:	Gaber, Mohamed H., Wu, Ning Z., Hong, Keelung, Huang, Shi Kun, Dewhirst, Mark W., Papahadjopoulos, Demetrios
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacokinetics Biological and medical sciences Carcinoma Doxorubicin Doxorubicin - pharmacokinetics Drug Carriers Extravasation Female Hot Temperature Hyperthermia Induced hyperthermia. Cryotherapy Liposomes Medical sciences Neoplasms, Experimental - blood supply Neoplasms, Experimental - drug therapy Rats Rats, Inbred F344 Thermosensitive liposomes Treatment with physical agents Treatment. General aspects Tumors Window chamber
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