Positive and negative modulation of H-ras transforming potential by mutations of phenylalanine-28

Conserved amino-acids of H-ras from residues 25 to 34 were mutated in human H-ras cDNA with a pre-existing valine-12 activating mutation ([V12]p21), and built into SV40-driven expression vectors. The influence of the introduced mutations was initially screened by transfection of Rat-1 cells to score...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular biology reports 1996-01, Vol.23 (2), p.109-117
Hauptverfasser:	Ricketts, M H, Durrheim, G A, North, H M, van der Merwe, M J, Levinson, A D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division Cell Line Cell Transformation, Neoplastic Gene Expression Guanosine Triphosphate - metabolism Humans Phenylalanine Proto-Oncogene Proteins p21(ras) - genetics Rats Signal Transduction Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!