A model for Batten disease protein CLN3: Functional implications from homology and mutations

In an attempt to understand the molecular nature of Batten disease, we have examined the amino acid sequence of the affected CLN3 gene product (The International Batten Disease Consortium (1995) Cell 82, 949–957) and the site-specific mutations which give rise to the biological defect. Homology sear...

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Veröffentlicht in:	FEBS letters 1996-12, Vol.399 (1), p.75-77
Hauptverfasser:	Janes, Robert W., Munroe, Patricia B., Mitchison, Hannah M., Mark Gardiner, R., Mole, Sara E., Wallace, B.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Chaperone Cyclins Genetic disease Humans Membrane Glycoproteins - genetics Membrane protein Molecular Chaperones - genetics Molecular modeling Molecular Sequence Data Mutation Neurodegenerative disease Neuronal Ceroid-Lipofuscinoses - genetics Saccharomyces cerevisiae Proteins Sequence Homology, Amino Acid
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