Involvement of sphingolipids in the endothelin-1 signal transduction mechanism in rat brain

In cerebral cortex, endothelin-1 (ET-1) evoked a decrease of 40% in sphingomyelin (SM) levels together with an increase in both ceramide and glycosphingolipid (GSL) levels (100 and 56% respectively). These facts indicate that ET-1 increases sphingomyelinase activity and, possibly, activates the synt...

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Veröffentlicht in:	Neuroscience letters 1996-12, Vol.220 (2), p.121-124
Hauptverfasser:	CATALAN, R. E, ARAGONES, M. D, MARTINEZ, A. M, FERNANDEZ, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Brain Brain - metabolism Central nervous system Ceramide Ceramides - metabolism Cerebellum - metabolism Cerebral Cortex - metabolism Endothelin-1 Endothelin-1 - pharmacology Fundamental and applied biological sciences. Psychology Glycosphingolipids Glycosphingolipids - metabolism Hydrolysis Rats Signal Transduction - drug effects Sphingomyelin Vertebrates: nervous system and sense organs
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