Effect of Oral Pretreatment with Indomethacin on the Intestinal First-Pass Metabolism of Salicylamide in Rabbits
The effect of oral pretreatment with indomethacin on the intestinal first-pass metabolism of salicylamide (SAM) was studied in rabbits using in situ intestinal sacs with complete mesenteric venous blood collection. The appearance of both SAM and its metabolites into the mesenteric venous blood was m...
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| Veröffentlicht in: | Journal of Pharmacobio-Dynamics 1988, Vol.11(9), pp.620-624 |
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| container_end_page | 624 |
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| container_title | Journal of Pharmacobio-Dynamics |
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| creator | NAKAMURA, Junzo SEKI, Nobuaki SASAKI, Hitoshi SHIBASAKI, Juichiro |
| description | The effect of oral pretreatment with indomethacin on the intestinal first-pass metabolism of salicylamide (SAM) was studied in rabbits using in situ intestinal sacs with complete mesenteric venous blood collection. The appearance of both SAM and its metabolites into the mesenteric venous blood was measured directly by cannulating the mesenteric vein of exposed rabbit intestine and collecting all venous blood draining from the absorbing region. By oral pretreatment with indomethacin, the total amounts of SAM absorbed in 20 and 120 min were significantly increased compared to the control. These results indicated the alteration of the permeability in the intestinal mucosa. In 20 min, indomethacin pretreatment resulted in increased appearance of SAM and SAM glucuronide in the mesenteric venous blood. In 120 min, increased appearance of SAM and decreased appearance of SAM sulfate were observed, compared to the control. These findings suggested that the change in the intestinal first-pass metabolism of SAM is probably due to the intestinal mucosal damage by oral pretreatment with indomethacin. |
| doi_str_mv | 10.1248/bpb1978.11.620 |
| format | Article |
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The appearance of both SAM and its metabolites into the mesenteric venous blood was measured directly by cannulating the mesenteric vein of exposed rabbit intestine and collecting all venous blood draining from the absorbing region. By oral pretreatment with indomethacin, the total amounts of SAM absorbed in 20 and 120 min were significantly increased compared to the control. These results indicated the alteration of the permeability in the intestinal mucosa. In 20 min, indomethacin pretreatment resulted in increased appearance of SAM and SAM glucuronide in the mesenteric venous blood. In 120 min, increased appearance of SAM and decreased appearance of SAM sulfate were observed, compared to the control. These findings suggested that the change in the intestinal first-pass metabolism of SAM is probably due to the intestinal mucosal damage by oral pretreatment with indomethacin.</description><identifier>ISSN: 0386-846X</identifier><identifier>EISSN: 1881-1353</identifier><identifier>DOI: 10.1248/bpb1978.11.620</identifier><identifier>PMID: 3216283</identifier><identifier>CODEN: JOPHDQ</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Administration, Oral ; Analgesics ; Animals ; Biological and medical sciences ; General pharmacology ; Indomethacin - administration & dosage ; Indomethacin - pharmacology ; Intestinal Mucosa - metabolism ; Male ; Medical sciences ; Neuropharmacology ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. 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The appearance of both SAM and its metabolites into the mesenteric venous blood was measured directly by cannulating the mesenteric vein of exposed rabbit intestine and collecting all venous blood draining from the absorbing region. By oral pretreatment with indomethacin, the total amounts of SAM absorbed in 20 and 120 min were significantly increased compared to the control. These results indicated the alteration of the permeability in the intestinal mucosa. In 20 min, indomethacin pretreatment resulted in increased appearance of SAM and SAM glucuronide in the mesenteric venous blood. In 120 min, increased appearance of SAM and decreased appearance of SAM sulfate were observed, compared to the control. These findings suggested that the change in the intestinal first-pass metabolism of SAM is probably due to the intestinal mucosal damage by oral pretreatment with indomethacin.</description><subject>Administration, Oral</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Indomethacin - administration & dosage</subject><subject>Indomethacin - pharmacology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Premedication</subject><subject>rabbit</subject><subject>Rabbits</subject><subject>Salicylamides - metabolism</subject><issn>0386-846X</issn><issn>1881-1353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1rGzEUxEVpSd20194KOpTe1tVb7WrlYzFJG0hJaBrITTzJT7XCfriSTMh_Hxkvprde9EDzm2EYxj6CWELd6K92Z2HV6SXAUtXiFVuA1lCBbOVrthBSq0o36uEte5fSoxDNSrdwxs5kDarWcsF2F96Ty3zy_CZiz28j5UiYBxozfwp5y6_GzTRQ3qILI59GnrdU_jKlHMZiuAwx5eoWU-I_KaOd-pCGQ9wd9sE99ziEDfFi_YXWhpzeszce-0Qf5nvO7i8vfq9_VNc336_W364r1zYyV1q2AoRXQAqkF7X1qkO0wsvaCmwbQrVpu85JBw7IkUKPzlKNXUfg0Mtz9uWYu4vT331pa4aQHPU9jjTtk-m0kkpoXcDlEXRxSimSN7sYBozPBoQ5TGzmiQ2AKRMXw6c5eW8H2pzwedOif551TA57H3F0IZ0wpVSrdfNfrO0UwKHe-og9pox_6KRjzMH19G-51fEpHU-q22I0NMoXa32qdw</recordid><startdate>19880901</startdate><enddate>19880901</enddate><creator>NAKAMURA, Junzo</creator><creator>SEKI, Nobuaki</creator><creator>SASAKI, Hitoshi</creator><creator>SHIBASAKI, Juichiro</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880901</creationdate><title>Effect of Oral Pretreatment with Indomethacin on the Intestinal First-Pass Metabolism of Salicylamide in Rabbits</title><author>NAKAMURA, Junzo ; SEKI, Nobuaki ; SASAKI, Hitoshi ; SHIBASAKI, Juichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-835010f61e613f02bf67aab0f32b0a54ea6d577c3c1c1ece6afacbe2a77e1caf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Administration, Oral</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Indomethacin - administration & dosage</topic><topic>Indomethacin - pharmacology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Premedication</topic><topic>rabbit</topic><topic>Rabbits</topic><topic>Salicylamides - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>NAKAMURA, Junzo</creatorcontrib><creatorcontrib>SEKI, Nobuaki</creatorcontrib><creatorcontrib>SASAKI, Hitoshi</creatorcontrib><creatorcontrib>SHIBASAKI, Juichiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Pharmacobio-Dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAKAMURA, Junzo</au><au>SEKI, Nobuaki</au><au>SASAKI, Hitoshi</au><au>SHIBASAKI, Juichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Oral Pretreatment with Indomethacin on the Intestinal First-Pass Metabolism of Salicylamide in Rabbits</atitle><jtitle>Journal of Pharmacobio-Dynamics</jtitle><addtitle>Journal of Pharmacobio-Dynamics</addtitle><date>1988-09-01</date><risdate>1988</risdate><volume>11</volume><issue>9</issue><spage>620</spage><epage>624</epage><pages>620-624</pages><issn>0386-846X</issn><eissn>1881-1353</eissn><coden>JOPHDQ</coden><abstract>The effect of oral pretreatment with indomethacin on the intestinal first-pass metabolism of salicylamide (SAM) was studied in rabbits using in situ intestinal sacs with complete mesenteric venous blood collection. The appearance of both SAM and its metabolites into the mesenteric venous blood was measured directly by cannulating the mesenteric vein of exposed rabbit intestine and collecting all venous blood draining from the absorbing region. By oral pretreatment with indomethacin, the total amounts of SAM absorbed in 20 and 120 min were significantly increased compared to the control. These results indicated the alteration of the permeability in the intestinal mucosa. In 20 min, indomethacin pretreatment resulted in increased appearance of SAM and SAM glucuronide in the mesenteric venous blood. In 120 min, increased appearance of SAM and decreased appearance of SAM sulfate were observed, compared to the control. These findings suggested that the change in the intestinal first-pass metabolism of SAM is probably due to the intestinal mucosal damage by oral pretreatment with indomethacin.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>3216283</pmid><doi>10.1248/bpb1978.11.620</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Pharmacobio-Dynamics, 1988, Vol.11(9), pp.620-624 |
| issn | 0386-846X 1881-1353 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Oral Analgesics Animals Biological and medical sciences General pharmacology Indomethacin - administration & dosage Indomethacin - pharmacology Intestinal Mucosa - metabolism Male Medical sciences Neuropharmacology Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Premedication rabbit Rabbits Salicylamides - metabolism |
| title | Effect of Oral Pretreatment with Indomethacin on the Intestinal First-Pass Metabolism of Salicylamide in Rabbits |
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