Oxidized low-density lipoprotein induces the production of interleukin-8 by endothelial cells

The concentration of interleukin-8 (IL-8) and RANTES was measured in culture supernatants of human EA.hy 926 endothelial cells incubated with oxidized low-density lipoproteins (LDL). Oxidized LDL induced a 3-fold increase in IL-8 production ( p < 0.01), whereas RANTES was not detected. Native LDL...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 1996-12, Vol.398 (2), p.223-227
Hauptverfasser:	Claise, Catherine, Edeas, Marvin, Chalas, Jacqueline, Cockx, Anélie, Abella, Annie, Capel, Liliane, Lindenbaum, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Atherosclerosis BSO Catalase - metabolism Cell Line Chemokine CCL5 - biosynthesis Dose-Response Relationship, Drug EA.hy 926 endothelial cell Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Free Radicals - metabolism glutathione peroxidase Glutathione Peroxidase - metabolism Gpx Humans IL-8 Interleukin-8 Interleukin-8 - biosynthesis Lipoproteins, LDL - pharmacology N-acetylcysteine NAC NF-kB nuclear factor-kappaB ox-LDL Oxidation-Reduction Oxidized low-density lipoprotein oxidized low-density lipoproteins PMNs polymorphonuclear neutrophils R-sulphoximine RANTES Reactive oxygen species Reactive Oxygen Species - metabolism regulated on activation normal T expressed and secreted chemokine SOD superoxide dismutase Superoxide Dismutase - metabolism Transforming Growth Factor beta - pharmacology Tumor Necrosis Factor-alpha - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!