Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX) in the CA3 region of the in vitro hippocampus
Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX) antagonized kainate-induced bursts and bursts of unknown origin in the CA3 region. CNQX also increased the latency of and eventually blocked evoked bursts which persist following kainate washout. In contrast, d-(−)-2...
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| Veröffentlicht in: | Brain research 1988-11, Vol.474 (1), p.201-203 |
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| creator | Neuman, R.S. Ben-Ari, Y. Cherubini, E. |
| description | Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX) antagonized kainate-induced bursts and bursts of unknown origin in the CA3 region. CNQX also increased the latency of and eventually blocked evoked bursts which persist following kainate washout. In contrast,
d-(−)-2-amino-7-phosphonoheptanoic acid did not alter burst latency or block bursts unless applied subsequent to CNQX. We conclude that the quisqualate type receptor has a prominent role in burst generation with a smaller contribution from
N-methyl-
d-aspartate receptors. |
| doi_str_mv | 10.1016/0006-8993(88)90686-5 |
| format | Article |
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d-(−)-2-amino-7-phosphonoheptanoic acid did not alter burst latency or block bursts unless applied subsequent to CNQX. We conclude that the quisqualate type receptor has a prominent role in burst generation with a smaller contribution from
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d-(−)-2-amino-7-phosphonoheptanoic acid did not alter burst latency or block bursts unless applied subsequent to CNQX. We conclude that the quisqualate type receptor has a prominent role in burst generation with a smaller contribution from
N-methyl-
d-aspartate receptors.</description><subject>6-Cyano-7-nitroquinoxaline-2, 3-dione</subject><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Burst</subject><subject>Central nervous system</subject><subject>d-(−)-2-Amino-7-phosphonoheptanoic acid</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>In Vitro Techniques</subject><subject>Kainate</subject><subject>Kainic Acid - pharmacology</subject><subject>Male</subject><subject>Quinoxalines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reaction Time - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd-K1DAUxoMo67j6Bgq5ENkFoyfNNE1vhGFY_8CiCArehTQ53Y22STdpB-cRfOttnWEu9SqcfL_vnJN8hDzn8IYDl28BQDJV1-JCqcsapJKsfEBWXFUFk8UaHpLVCXlMnuT8cy6FqOGMnBU1lJLLFfmzCaO5icHnnsaW5iHOdcA4ZWqCo7iLv9DRZkp5zLTZU8ns3oTIKhb8mOLd5EP8bTofkBWvqWDOx4D0Yvv5649L6gMdb5FuN4ImvJmVZcRyMwu7xU5v_TBEa_phyk_Jo9Z0GZ8dz3Py_f3Vt-1Hdv3lw6ft5ppZIYqRlbVFIY3kAFUDRcuts5WrnWhxbaFxolEKy7KFQjoFgpeOq6bmUArRNqpqxDl5deg7LOtjHnXvs8WuOzxbV0oKLmT9X5CXvFoLDjO4PoA2xZwTtnpIvjdprznoJSq95KCXHLRS-m9UupxtL479p6ZHdzIds5n1l0fdZGu6NplgfT5hVVHwCtSMvTtgOH_azmPS2XoMFp1PaEftov_3Hvdk-a7j</recordid><startdate>19881122</startdate><enddate>19881122</enddate><creator>Neuman, R.S.</creator><creator>Ben-Ari, Y.</creator><creator>Cherubini, E.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19881122</creationdate><title>Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX) in the CA3 region of the in vitro hippocampus</title><author>Neuman, R.S. ; Ben-Ari, Y. ; Cherubini, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-59ce36a61007b02f1cdc7d9d3fe4c0bd3b88e55f026d80315d18b910533fb87b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>6-Cyano-7-nitroquinoxaline-2, 3-dione</topic><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Burst</topic><topic>Central nervous system</topic><topic>d-(−)-2-Amino-7-phosphonoheptanoic acid</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>In Vitro Techniques</topic><topic>Kainate</topic><topic>Kainic Acid - pharmacology</topic><topic>Male</topic><topic>Quinoxalines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reaction Time - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neuman, R.S.</creatorcontrib><creatorcontrib>Ben-Ari, Y.</creatorcontrib><creatorcontrib>Cherubini, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neuman, R.S.</au><au>Ben-Ari, Y.</au><au>Cherubini, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX) in the CA3 region of the in vitro hippocampus</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1988-11-22</date><risdate>1988</risdate><volume>474</volume><issue>1</issue><spage>201</spage><epage>203</epage><pages>201-203</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX) antagonized kainate-induced bursts and bursts of unknown origin in the CA3 region. CNQX also increased the latency of and eventually blocked evoked bursts which persist following kainate washout. In contrast,
d-(−)-2-amino-7-phosphonoheptanoic acid did not alter burst latency or block bursts unless applied subsequent to CNQX. We conclude that the quisqualate type receptor has a prominent role in burst generation with a smaller contribution from
N-methyl-
d-aspartate receptors.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2905616</pmid><doi>10.1016/0006-8993(88)90686-5</doi><tpages>3</tpages></addata></record> |
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| subjects | 6-Cyano-7-nitroquinoxaline-2, 3-dione Action Potentials - drug effects Animals Biological and medical sciences Burst Central nervous system d-(−)-2-Amino-7-phosphonoheptanoic acid Electrophysiology Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Kainate Kainic Acid - pharmacology Male Quinoxalines - pharmacology Rats Rats, Inbred Strains Reaction Time - drug effects Vertebrates: nervous system and sense organs |
| title | Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX) in the CA3 region of the in vitro hippocampus |
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