Atrial Natriuretic Peptide in Kidney of Renal Disease Patients and Healthy Persons
Regulation of renal excretion of atrial natriuretic peptide (ANP) was studied in kidney disease patients and healthy kidney donors. The measured ANP concentration in the patient's plasma did not correlate with their creatinine clearance (Ccr), while the fractional excretion of ANP (FEANP) signi...
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| Veröffentlicht in: | Endocrinologia Japonica 1988, Vol.35(4), pp.523-529 |
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| container_issue | 4 |
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| container_title | Endocrinologia Japonica |
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| creator | MARUMO, FUMIAKI SAKAMOTO, HISATO UMETANI, NAOKI OKUBO, MICHIHITO |
| description | Regulation of renal excretion of atrial natriuretic peptide (ANP) was studied in kidney disease patients and healthy kidney donors. The measured ANP concentration in the patient's plasma did not correlate with their creatinine clearance (Ccr), while the fractional excretion of ANP (FEANP) significantly correlated with Ccr. FEANP in healthy persons is less than 1%. In the healthy donors of kidneys for transplantation, approximately 80% of the plasma ANP from the renal artery appeared in the renal vein. From these results, this high recovery of ANP in the veins does not appear to be adequately explained by its degradation in the renal arterioles and nephrons. The FEANP from kidney disease patients significantly correlated with FENa, FEK and FEp, but not with FEca and FEMg. The manner of ANP handling in the nephron may possibly differ from that of Ca or Mg. |
| doi_str_mv | 10.1507/endocrj1954.35.523 |
| format | Article |
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The measured ANP concentration in the patient's plasma did not correlate with their creatinine clearance (Ccr), while the fractional excretion of ANP (FEANP) significantly correlated with Ccr. FEANP in healthy persons is less than 1%. In the healthy donors of kidneys for transplantation, approximately 80% of the plasma ANP from the renal artery appeared in the renal vein. From these results, this high recovery of ANP in the veins does not appear to be adequately explained by its degradation in the renal arterioles and nephrons. The FEANP from kidney disease patients significantly correlated with FENa, FEK and FEp, but not with FEca and FEMg. The manner of ANP handling in the nephron may possibly differ from that of Ca or Mg.</description><identifier>ISSN: 0013-7219</identifier><identifier>EISSN: 2185-6370</identifier><identifier>DOI: 10.1507/endocrj1954.35.523</identifier><identifier>PMID: 2975217</identifier><identifier>CODEN: ECJPAE</identifier><language>eng</language><publisher>Tokyo: The Japan Endocrine Society</publisher><subject>Adolescent ; Adult ; Aged ; Atrial Natriuretic Factor - blood ; Atrial Natriuretic Factor - metabolism ; Atrial Natriuretic Factor - urine ; Biological and medical sciences ; Female ; Humans ; Kidney - analysis ; Kidney - metabolism ; Kidney Diseases - blood ; Kidney Diseases - metabolism ; Kidney Diseases - urine ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases</subject><ispartof>Endocrinologia Japonica, 1988, Vol.35(4), pp.523-529</ispartof><rights>The Japan Endocrine Society</rights><rights>1990 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6715222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2975217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARUMO, FUMIAKI</creatorcontrib><creatorcontrib>SAKAMOTO, HISATO</creatorcontrib><creatorcontrib>UMETANI, NAOKI</creatorcontrib><creatorcontrib>OKUBO, MICHIHITO</creatorcontrib><title>Atrial Natriuretic Peptide in Kidney of Renal Disease Patients and Healthy Persons</title><title>Endocrinologia Japonica</title><addtitle>Endocrinol Japon</addtitle><description>Regulation of renal excretion of atrial natriuretic peptide (ANP) was studied in kidney disease patients and healthy kidney donors. The measured ANP concentration in the patient's plasma did not correlate with their creatinine clearance (Ccr), while the fractional excretion of ANP (FEANP) significantly correlated with Ccr. FEANP in healthy persons is less than 1%. In the healthy donors of kidneys for transplantation, approximately 80% of the plasma ANP from the renal artery appeared in the renal vein. From these results, this high recovery of ANP in the veins does not appear to be adequately explained by its degradation in the renal arterioles and nephrons. The FEANP from kidney disease patients significantly correlated with FENa, FEK and FEp, but not with FEca and FEMg. The manner of ANP handling in the nephron may possibly differ from that of Ca or Mg.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Atrial Natriuretic Factor - metabolism</subject><subject>Atrial Natriuretic Factor - urine</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney - analysis</subject><subject>Kidney - metabolism</subject><subject>Kidney Diseases - blood</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><issn>0013-7219</issn><issn>2185-6370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0U1LAzEQBuAgSi21f0AQchBvW_PRbHaPxW8UlaLnZXYza1O22Zqkh_57A12Kc8gc3idzmCHkkrMZV0zfojN949e8VPOZVDMl5AkZC16oLJeanZIxY1xmWvDynExDWLNUucj1nI3ISJRaCa7HZLmI3kJH3yH1ncdoG_qJ22gNUuvoqzUO97Rv6RJdYvc2IASknxAtuhgoOEOfEbq42qd_PvQuXJCzFrqA06FPyPfjw9fdc_b28fRyt3jL1qIsY9YUEoVmQre1EVK2oqgReakbw-cgtCpNa6SUoHLkLZQStQGuTMJMt7qu5YTcHOZuff-7wxCrjQ0Ndh047Heh0kUuuShkglcD3NUbNNXW2w34fTUsIeXXQw6hga714BobjizXXAkhEns6sHWI8IPHHHxaWofVv4NUUlXDk-5yFM0KfGLyD003hwo</recordid><startdate>19880801</startdate><enddate>19880801</enddate><creator>MARUMO, FUMIAKI</creator><creator>SAKAMOTO, HISATO</creator><creator>UMETANI, NAOKI</creator><creator>OKUBO, MICHIHITO</creator><general>The Japan Endocrine Society</general><general>Japan Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19880801</creationdate><title>Atrial Natriuretic Peptide in Kidney of Renal Disease Patients and Healthy Persons</title><author>MARUMO, FUMIAKI ; SAKAMOTO, HISATO ; UMETANI, NAOKI ; OKUBO, MICHIHITO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j299t-c83e27027fbd233f28bee197cd14a2759dfd333a56e1fa93e7da15dbd207f7bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>Atrial Natriuretic Factor - metabolism</topic><topic>Atrial Natriuretic Factor - urine</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney - analysis</topic><topic>Kidney - metabolism</topic><topic>Kidney Diseases - blood</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><toplevel>online_resources</toplevel><creatorcontrib>MARUMO, FUMIAKI</creatorcontrib><creatorcontrib>SAKAMOTO, HISATO</creatorcontrib><creatorcontrib>UMETANI, NAOKI</creatorcontrib><creatorcontrib>OKUBO, MICHIHITO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinologia Japonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARUMO, FUMIAKI</au><au>SAKAMOTO, HISATO</au><au>UMETANI, NAOKI</au><au>OKUBO, MICHIHITO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial Natriuretic Peptide in Kidney of Renal Disease Patients and Healthy Persons</atitle><jtitle>Endocrinologia Japonica</jtitle><addtitle>Endocrinol Japon</addtitle><date>1988-08-01</date><risdate>1988</risdate><volume>35</volume><issue>4</issue><spage>523</spage><epage>529</epage><pages>523-529</pages><issn>0013-7219</issn><eissn>2185-6370</eissn><coden>ECJPAE</coden><abstract>Regulation of renal excretion of atrial natriuretic peptide (ANP) was studied in kidney disease patients and healthy kidney donors. The measured ANP concentration in the patient's plasma did not correlate with their creatinine clearance (Ccr), while the fractional excretion of ANP (FEANP) significantly correlated with Ccr. FEANP in healthy persons is less than 1%. In the healthy donors of kidneys for transplantation, approximately 80% of the plasma ANP from the renal artery appeared in the renal vein. From these results, this high recovery of ANP in the veins does not appear to be adequately explained by its degradation in the renal arterioles and nephrons. The FEANP from kidney disease patients significantly correlated with FENa, FEK and FEp, but not with FEca and FEMg. The manner of ANP handling in the nephron may possibly differ from that of Ca or Mg.</abstract><cop>Tokyo</cop><pub>The Japan Endocrine Society</pub><pmid>2975217</pmid><doi>10.1507/endocrj1954.35.523</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Endocrinologia Japonica, 1988, Vol.35(4), pp.523-529 |
| issn | 0013-7219 2185-6370 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78631283 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Atrial Natriuretic Factor - blood Atrial Natriuretic Factor - metabolism Atrial Natriuretic Factor - urine Biological and medical sciences Female Humans Kidney - analysis Kidney - metabolism Kidney Diseases - blood Kidney Diseases - metabolism Kidney Diseases - urine Male Medical sciences Middle Aged Nephrology. Urinary tract diseases |
| title | Atrial Natriuretic Peptide in Kidney of Renal Disease Patients and Healthy Persons |
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