Characterization of the furanocoumarin phellopterin as a rat brain benzodiazepine receptor partial agonist in vitro

Phellopterin, a naturally occurring furanocoumarin found in the roots of Angelica dahurica, inhibits [ 3H]diazepam and ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate ([ 3H]Ro 15-1788) binding to the benzodiazepine site of the rat brain γ-aminobutyric aci...

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Veröffentlicht in:	Neuroscience letters 1996-11, Vol.219 (3), p.151-154
Hauptverfasser:	Dekermendjian, Kim, Ai, Jinglu, Nielsen, Mogens, Sterner, Olov, Shan, Rudong, Witt, Michael-Robin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Brain - metabolism Bridged Bicyclo Compounds, Heterocyclic - metabolism Cell receptors Cell structures and functions Central nervous system Coumarins - pharmacology Diazepam - antagonists & inhibitors Diazepam - metabolism Flumazenil - metabolism Fundamental and applied biological sciences. Psychology Furanocoumarins GABA Modulators - metabolism GABA-A Receptor Agonists In Vitro Techniques Male Miscellaneous Molecular and cellular biology Partial agonist Phellopterin Rats Rats, Wistar Receptors, GABA - metabolism Receptors, GABA-A - metabolism γ-Aminobutyric acid A/benzodiazepine receptors
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