Casein Kinase I α and αL: Alternative Splicing-Generated Kinases Exhibit Different Catalytic Properties

Casein kinase I (CKI) is a family of serine/threonine protein kinases found in all eukaryotes examined to date. Here, the rat CKI isoforms α and αL were cloned and expressed in both eukaryotic and prokaryotic systems. Characterization of the genomic DNA flanking the exon unique to CKIαL demonstrated...

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Veröffentlicht in:	Biochemistry (Easton) 1996-12, Vol.35 (50), p.16319-16327
Hauptverfasser:	Zhang, Jiren, Gross, Stefan D, Schroeder, Matthew D, Anderson, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Animals Base Sequence Binding Sites Brain - enzymology Casein Kinases Catalysis Cattle DNA Primers Exons Glutathione Transferase - biosynthesis Introns Isoenzymes - biosynthesis Isoenzymes - chemistry Isoenzymes - metabolism Kinetics Molecular Sequence Data Polymerase Chain Reaction Protein Kinases - biosynthesis Protein Kinases - chemistry Protein Kinases - metabolism Rats Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism RNA Precursors - metabolism Sequence Homology, Amino Acid Substrate Specificity Transcription, Genetic
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