Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: A comparative animal study

The effective clinical use of the anticancer drug 5-fluorouracil (5-FU) requires the noninvasive assessment of its transport and metabolism, particularly in the tumor and the liver, where the drug is catabolized to α-fluoro-β-alanine (FBAL). In this study, the potentials and limitations of dynamic 1...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nuclear medicine and biology 1996-10, Vol.23 (7), p.897-906
Hauptverfasser:	Brix, Gunnar, Bellemann, Matthias E., Haberkorn, Uwe, Gerlach, Ludwig, Lorenz, Walter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chemotherapy Experimental neoplasms Fluorine Radioisotopes Fluorouracil - metabolism Fluorouracil - pharmacokinetics Liver - diagnostic imaging Liver - metabolism Liver Neoplasms, Experimental - diagnostic imaging Liver Neoplasms, Experimental - metabolism Magnetic Resonance Imaging Male Medical sciences Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - metabolism Positron emission tomography Rats Rats, Inbred ACI Rats, Inbred BUF Tissue Distribution Tomography, Emission-Computed Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!