Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: A comparative animal study
The effective clinical use of the anticancer drug 5-fluorouracil (5-FU) requires the noninvasive assessment of its transport and metabolism, particularly in the tumor and the liver, where the drug is catabolized to α-fluoro-β-alanine (FBAL). In this study, the potentials and limitations of dynamic 1...
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| Veröffentlicht in: | Nuclear medicine and biology 1996-10, Vol.23 (7), p.897-906 |
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| creator | Brix, Gunnar Bellemann, Matthias E. Haberkorn, Uwe Gerlach, Ludwig Lorenz, Walter J. |
| description | The effective clinical use of the anticancer drug 5-fluorouracil (5-FU) requires the noninvasive assessment of its transport and metabolism, particularly in the tumor and the liver, where the drug is catabolized to α-fluoro-β-alanine (FBAL). In this study, the potentials and limitations of dynamic
18F PET and metabolic
19F MRI examinations for noninvasive 5-FU monitoring were investigated in ACI and Buffalo rats with transplanted MH3924A and TC5123 Morris hepatomas, respectively. Selective 5-[
19F]FU and [
19F]FBAL MR images were acquired 5 and 70 min after 5-FU injection using a CHESS MRI sequence. After administration of 5-[
18F]FU, the kinetics of the regional 5-[
18F]FU uptake were measured by dynamic PET scanning over 120 min. To allow a comparison between PET and MRI data, standardized uptake values (SUV) were computed at the same points in time. The TC5123 hepatoma showed a significantly (
p < 0.002) higher mean SUV at 5 and 70 min post-5-FU injection than the MH3924A cell lines, whereas there were no significant differences between the mean SUV measured in the liver of both animal populations. In contrast to the PET data, no significant differences in the mean 5-[
19F]FU and [
19F]FBAL MR signal values in the tumor of both models were observed. The MR images, however, yielded the additional information that 5-FU is converted to FBAL only in the liver and not in the hepatomas. |
| doi_str_mv | 10.1016/S0969-8051(96)00122-9 |
| format | Article |
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18F PET and metabolic
19F MRI examinations for noninvasive 5-FU monitoring were investigated in ACI and Buffalo rats with transplanted MH3924A and TC5123 Morris hepatomas, respectively. Selective 5-[
19F]FU and [
19F]FBAL MR images were acquired 5 and 70 min after 5-FU injection using a CHESS MRI sequence. After administration of 5-[
18F]FU, the kinetics of the regional 5-[
18F]FU uptake were measured by dynamic PET scanning over 120 min. To allow a comparison between PET and MRI data, standardized uptake values (SUV) were computed at the same points in time. The TC5123 hepatoma showed a significantly (
p < 0.002) higher mean SUV at 5 and 70 min post-5-FU injection than the MH3924A cell lines, whereas there were no significant differences between the mean SUV measured in the liver of both animal populations. In contrast to the PET data, no significant differences in the mean 5-[
19F]FU and [
19F]FBAL MR signal values in the tumor of both models were observed. The MR images, however, yielded the additional information that 5-FU is converted to FBAL only in the liver and not in the hepatomas.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/S0969-8051(96)00122-9</identifier><identifier>PMID: 8971857</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>5-Fluorouracil ; Animals ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Chemotherapy ; Experimental neoplasms ; Fluorine Radioisotopes ; Fluorouracil - metabolism ; Fluorouracil - pharmacokinetics ; Liver - diagnostic imaging ; Liver - metabolism ; Liver Neoplasms, Experimental - diagnostic imaging ; Liver Neoplasms, Experimental - metabolism ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - metabolism ; Positron emission tomography ; Rats ; Rats, Inbred ACI ; Rats, Inbred BUF ; Tissue Distribution ; Tomography, Emission-Computed ; Tumors</subject><ispartof>Nuclear medicine and biology, 1996-10, Vol.23 (7), p.897-906</ispartof><rights>1996</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2367-4b6342db67eb8000827688b46e21c02e940337fb32c56d56f67d03fbb07bc4323</citedby><cites>FETCH-LOGICAL-c2367-4b6342db67eb8000827688b46e21c02e940337fb32c56d56f67d03fbb07bc4323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0969-8051(96)00122-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2500583$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8971857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brix, Gunnar</creatorcontrib><creatorcontrib>Bellemann, Matthias E.</creatorcontrib><creatorcontrib>Haberkorn, Uwe</creatorcontrib><creatorcontrib>Gerlach, Ludwig</creatorcontrib><creatorcontrib>Lorenz, Walter J.</creatorcontrib><title>Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: A comparative animal study</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>The effective clinical use of the anticancer drug 5-fluorouracil (5-FU) requires the noninvasive assessment of its transport and metabolism, particularly in the tumor and the liver, where the drug is catabolized to α-fluoro-β-alanine (FBAL). In this study, the potentials and limitations of dynamic
18F PET and metabolic
19F MRI examinations for noninvasive 5-FU monitoring were investigated in ACI and Buffalo rats with transplanted MH3924A and TC5123 Morris hepatomas, respectively. Selective 5-[
19F]FU and [
19F]FBAL MR images were acquired 5 and 70 min after 5-FU injection using a CHESS MRI sequence. After administration of 5-[
18F]FU, the kinetics of the regional 5-[
18F]FU uptake were measured by dynamic PET scanning over 120 min. To allow a comparison between PET and MRI data, standardized uptake values (SUV) were computed at the same points in time. The TC5123 hepatoma showed a significantly (
p < 0.002) higher mean SUV at 5 and 70 min post-5-FU injection than the MH3924A cell lines, whereas there were no significant differences between the mean SUV measured in the liver of both animal populations. In contrast to the PET data, no significant differences in the mean 5-[
19F]FU and [
19F]FBAL MR signal values in the tumor of both models were observed. The MR images, however, yielded the additional information that 5-FU is converted to FBAL only in the liver and not in the hepatomas.</description><subject>5-Fluorouracil</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Chemotherapy</subject><subject>Experimental neoplasms</subject><subject>Fluorine Radioisotopes</subject><subject>Fluorouracil - metabolism</subject><subject>Fluorouracil - pharmacokinetics</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - metabolism</subject><subject>Liver Neoplasms, Experimental - diagnostic imaging</subject><subject>Liver Neoplasms, Experimental - metabolism</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Positron emission tomography</subject><subject>Rats</subject><subject>Rats, Inbred ACI</subject><subject>Rats, Inbred BUF</subject><subject>Tissue Distribution</subject><subject>Tomography, Emission-Computed</subject><subject>Tumors</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEuLFDEURoMoYzv6EwayENFFaR5VScrN0AzTOjCi6LgOedzCSFWlTVIDvfWXm37QW1e58J3v5nIQuqLkPSVUfPhBetE3inT0bS_eEUIZa_onaEWVrIOg7VO0OiPP0Yucf1dItJRcoAvVS6o6uUJ_1zlDzhPMBccBl1-AbYg-5JKCXUqIMzazxxMUY-MY8rSnumYYl5jikowLIzYZT3EOJSbw2O4wVRv87fbhUKT9Bn_5fvcRr7GL09YkU8Ij1ChMZsS5LH73Ej0bzJjh1em9RD83tw83n5v7r5_ubtb3jWNcyKa1grfMWyHBKkKIYlIoZVsBjDrCoG8J53KwnLlO-E4MQnrCB2uJtK7ljF-iN8e92xT_LJCLnkJ2MI5mhrhkLZWoK6WsYHcEXYo5Jxj0NtVz005Tovfu9cG93ovVvdAH97qvvavTB4udwJ9bJ9k1f33KTXZmHJKZXchnjHWEdIpX7PqIQZXxGCDp7ALMDnxI4Ir2MfznkH8Jdp83</recordid><startdate>199610</startdate><enddate>199610</enddate><creator>Brix, Gunnar</creator><creator>Bellemann, Matthias E.</creator><creator>Haberkorn, Uwe</creator><creator>Gerlach, Ludwig</creator><creator>Lorenz, Walter J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199610</creationdate><title>Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: A comparative animal study</title><author>Brix, Gunnar ; Bellemann, Matthias E. ; Haberkorn, Uwe ; Gerlach, Ludwig ; Lorenz, Walter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2367-4b6342db67eb8000827688b46e21c02e940337fb32c56d56f67d03fbb07bc4323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>5-Fluorouracil</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Chemotherapy</topic><topic>Experimental neoplasms</topic><topic>Fluorine Radioisotopes</topic><topic>Fluorouracil - metabolism</topic><topic>Fluorouracil - pharmacokinetics</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - metabolism</topic><topic>Liver Neoplasms, Experimental - diagnostic imaging</topic><topic>Liver Neoplasms, Experimental - metabolism</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Positron emission tomography</topic><topic>Rats</topic><topic>Rats, Inbred ACI</topic><topic>Rats, Inbred BUF</topic><topic>Tissue Distribution</topic><topic>Tomography, Emission-Computed</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brix, Gunnar</creatorcontrib><creatorcontrib>Bellemann, Matthias E.</creatorcontrib><creatorcontrib>Haberkorn, Uwe</creatorcontrib><creatorcontrib>Gerlach, Ludwig</creatorcontrib><creatorcontrib>Lorenz, Walter J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brix, Gunnar</au><au>Bellemann, Matthias E.</au><au>Haberkorn, Uwe</au><au>Gerlach, Ludwig</au><au>Lorenz, Walter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: A comparative animal study</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>1996-10</date><risdate>1996</risdate><volume>23</volume><issue>7</issue><spage>897</spage><epage>906</epage><pages>897-906</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>The effective clinical use of the anticancer drug 5-fluorouracil (5-FU) requires the noninvasive assessment of its transport and metabolism, particularly in the tumor and the liver, where the drug is catabolized to α-fluoro-β-alanine (FBAL). In this study, the potentials and limitations of dynamic
18F PET and metabolic
19F MRI examinations for noninvasive 5-FU monitoring were investigated in ACI and Buffalo rats with transplanted MH3924A and TC5123 Morris hepatomas, respectively. Selective 5-[
19F]FU and [
19F]FBAL MR images were acquired 5 and 70 min after 5-FU injection using a CHESS MRI sequence. After administration of 5-[
18F]FU, the kinetics of the regional 5-[
18F]FU uptake were measured by dynamic PET scanning over 120 min. To allow a comparison between PET and MRI data, standardized uptake values (SUV) were computed at the same points in time. The TC5123 hepatoma showed a significantly (
p < 0.002) higher mean SUV at 5 and 70 min post-5-FU injection than the MH3924A cell lines, whereas there were no significant differences between the mean SUV measured in the liver of both animal populations. In contrast to the PET data, no significant differences in the mean 5-[
19F]FU and [
19F]FBAL MR signal values in the tumor of both models were observed. The MR images, however, yielded the additional information that 5-FU is converted to FBAL only in the liver and not in the hepatomas.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>8971857</pmid><doi>10.1016/S0969-8051(96)00122-9</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Nuclear medicine and biology, 1996-10, Vol.23 (7), p.897-906 |
| issn | 0969-8051 1872-9614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78627677 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 5-Fluorouracil Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chemotherapy Experimental neoplasms Fluorine Radioisotopes Fluorouracil - metabolism Fluorouracil - pharmacokinetics Liver - diagnostic imaging Liver - metabolism Liver Neoplasms, Experimental - diagnostic imaging Liver Neoplasms, Experimental - metabolism Magnetic Resonance Imaging Male Medical sciences Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - metabolism Positron emission tomography Rats Rats, Inbred ACI Rats, Inbred BUF Tissue Distribution Tomography, Emission-Computed Tumors |
| title | Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: A comparative animal study |
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