Free radical scavengers suppress the accumulation of platinum in the cerebral cortex

We investigated whether free radical scavengers and antioxidants inhibit the accumulation of platinum (Pt) in the cerebral cortex. Pt was detected in the cerebral cortex of mice after administration of cisplatin and exposure to short-term hypoxia. When mice were treated with either allopurinol (20 m...

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Veröffentlicht in:	Biological trace element research 1996-10, Vol.55 (1-2), p.1-7
Hauptverfasser:	Minami, T, Ichii, M, Okazaki, J, Kawaki, H, Okazaki, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopurinol - pharmacology Animals Antioxidants - pharmacology Ascorbic Acid - pharmacology Catalase - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cisplatin - pharmacokinetics Free Radical Scavengers - pharmacology Hypoxia Kinetics Lipid Peroxidation - drug effects Male Mice Mice, Inbred Strains Niacin - pharmacology Platinum - pharmacokinetics Vitamin E - pharmacology
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