Poststatin, a New Inhibitor of Prolyl Endopeptidase: VIII. Endopeptidase Inhibitory Activity of Non-peptidyl Poststatin Analogues

Non-peptidyl poststatin analogues, (S)-N-substituted-2-[2-1-acylpyrrolidinyl)]-2-oxoacetamides were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Many compounds showed stronger activity than natural poststatin, a pentapeptide. Among the...

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Veröffentlicht in:	Journal of antibiotics 1996/10/25, Vol.49(10), pp.1022-1030
Hauptverfasser:	TSUDA, MAKOTO, MURAOKA, YASUHIKO, NAGAI, MACHIKO, AOYAGI, TAKAAKI, TAKEUCHI, TOMIO
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Neuropharmacology Neuroprotective agent Oligopeptides - chemistry Oligopeptides - pharmacology Oxidation-Reduction Pharmacology. Drug treatments Serine Endopeptidases - drug effects Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - pharmacology Spectrometry, Mass, Fast Atom Bombardment Streptomyces Structure-Activity Relationship
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