Biological variation of lipids and lipoproteins in fingerstick blood
The biological variability of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and calculated low-density lipoprotein cholesterol (LDL-C) was determined in three serial (monthly) capillary and venous specimens from 83 subjects. The analytes were quantified wi...
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| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 1996-12, Vol.42 (12), p.2002-2007 |
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| container_end_page | 2007 |
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| container_issue | 12 |
| container_start_page | 2002 |
| container_title | Clinical chemistry (Baltimore, Md.) |
| container_volume | 42 |
| creator | Kafonek, SD Donovan, L Lovejoy, KL Bachorik, PS |
| description | The biological variability of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and calculated low-density lipoprotein cholesterol (LDL-C) was determined in three serial (monthly) capillary and venous specimens from 83 subjects. The analytes were quantified with a desktop analyzer. We saw no differences in the coefficient of biological variability (CVb) between capillary and venous specimens for any analyte (TC, 5.2%; TG, 14.7%; HDL-C, 7.2%; LDL-C, 5.4%). The average analytical variability (CVa) for each analyte, determined in quality-control pools, was; TC, 5.0%; TG, 5.2%; HDL-C, 5.8%; and LDL-C, 7.5%. Compared with standardized laboratory measurements, the desktop analyzer exhibited a significant (P < 0.001) positive bias for all analytes (average bias: TC, 5%; TG, 16%; HDL-C, 6%; and LDL-C, 2.4%). Thus, the biological variation of lipids and lipoproteins was the same in fingerstick and venous samples, and the desktop analyzer showed inherently greater analytical variability. |
| doi_str_mv | 10.1093/clinchem/42.12.2002 |
| format | Article |
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The analytes were quantified with a desktop analyzer. We saw no differences in the coefficient of biological variability (CVb) between capillary and venous specimens for any analyte (TC, 5.2%; TG, 14.7%; HDL-C, 7.2%; LDL-C, 5.4%). The average analytical variability (CVa) for each analyte, determined in quality-control pools, was; TC, 5.0%; TG, 5.2%; HDL-C, 5.8%; and LDL-C, 7.5%. Compared with standardized laboratory measurements, the desktop analyzer exhibited a significant (P < 0.001) positive bias for all analytes (average bias: TC, 5%; TG, 16%; HDL-C, 6%; and LDL-C, 2.4%). Thus, the biological variation of lipids and lipoproteins was the same in fingerstick and venous samples, and the desktop analyzer showed inherently greater analytical variability.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1093/clinchem/42.12.2002</identifier><identifier>PMID: 8969640</identifier><identifier>CODEN: CLCHAU</identifier><language>eng</language><publisher>Washington, DC: Am Assoc Clin Chem</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Capillaries ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Female ; Fingers - blood supply ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lipids - blood ; Lipoproteins - blood ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Point-of-Care Systems ; Quality Control ; Veins</subject><ispartof>Clinical chemistry (Baltimore, Md.), 1996-12, Vol.42 (12), p.2002-2007</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-9aed952de915be55a377505ece217312673bd2a2e0832975460a5f00612cb1c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2529171$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8969640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kafonek, SD</creatorcontrib><creatorcontrib>Donovan, L</creatorcontrib><creatorcontrib>Lovejoy, KL</creatorcontrib><creatorcontrib>Bachorik, PS</creatorcontrib><title>Biological variation of lipids and lipoproteins in fingerstick blood</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>The biological variability of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and calculated low-density lipoprotein cholesterol (LDL-C) was determined in three serial (monthly) capillary and venous specimens from 83 subjects. The analytes were quantified with a desktop analyzer. We saw no differences in the coefficient of biological variability (CVb) between capillary and venous specimens for any analyte (TC, 5.2%; TG, 14.7%; HDL-C, 7.2%; LDL-C, 5.4%). The average analytical variability (CVa) for each analyte, determined in quality-control pools, was; TC, 5.0%; TG, 5.2%; HDL-C, 5.8%; and LDL-C, 7.5%. Compared with standardized laboratory measurements, the desktop analyzer exhibited a significant (P < 0.001) positive bias for all analytes (average bias: TC, 5%; TG, 16%; HDL-C, 6%; and LDL-C, 2.4%). Thus, the biological variation of lipids and lipoproteins was the same in fingerstick and venous samples, and the desktop analyzer showed inherently greater analytical variability.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Capillaries</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Female</subject><subject>Fingers - blood supply</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lipids - blood</subject><subject>Lipoproteins - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Point-of-Care Systems</subject><subject>Quality Control</subject><subject>Veins</subject><issn>0009-9147</issn><issn>1530-8561</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRS0EKuXxBQgpCwSrtH4m8RLKU6rEBtaW4zitwbGLnRLx97hqqVh5rDlz7TkAXCA4QZCTqbLGqaXuphRPEJ5gCPEBGCNGYF6xAh2CMYSQ5xzR8hicxPiRrrSsihEYVbzgBYVjcH9nvPULo6TNvmUwsjfeZb7NrFmZJmbSNZvSr4LvtXExMy5rjVvoEHujPrPaet-cgaNW2qjPd-cpeH98eJs95_PXp5fZ7TxXFBZ9zqVuOMON5ojVmjFJypJBppXGqCQIFyWpGyyxhhXBvGS0gJK1EBYIqxopQk7B9TY3_eZrrWMvOhOVtlY67ddRpN0w5axKINmCKvgYg27FKphOhh-BoNi4E3_uBMUCYbFxl6Yud_HrutPNfmYnK_Wvdn0Zk682SKdM3GOYYY5KlLCbLbY0i-Vgghaxk9amUCSGYfj34C_CWoYJ</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Kafonek, SD</creator><creator>Donovan, L</creator><creator>Lovejoy, KL</creator><creator>Bachorik, PS</creator><general>Am Assoc Clin Chem</general><general>American Association for Clinical Chemistry</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Biological variation of lipids and lipoproteins in fingerstick blood</title><author>Kafonek, SD ; Donovan, L ; Lovejoy, KL ; Bachorik, PS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-9aed952de915be55a377505ece217312673bd2a2e0832975460a5f00612cb1c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Capillaries</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Female</topic><topic>Fingers - blood supply</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lipids - blood</topic><topic>Lipoproteins - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Point-of-Care Systems</topic><topic>Quality Control</topic><topic>Veins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kafonek, SD</creatorcontrib><creatorcontrib>Donovan, L</creatorcontrib><creatorcontrib>Lovejoy, KL</creatorcontrib><creatorcontrib>Bachorik, PS</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kafonek, SD</au><au>Donovan, L</au><au>Lovejoy, KL</au><au>Bachorik, PS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological variation of lipids and lipoproteins in fingerstick blood</atitle><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle><addtitle>Clin Chem</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>42</volume><issue>12</issue><spage>2002</spage><epage>2007</epage><pages>2002-2007</pages><issn>0009-9147</issn><eissn>1530-8561</eissn><coden>CLCHAU</coden><abstract>The biological variability of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and calculated low-density lipoprotein cholesterol (LDL-C) was determined in three serial (monthly) capillary and venous specimens from 83 subjects. The analytes were quantified with a desktop analyzer. We saw no differences in the coefficient of biological variability (CVb) between capillary and venous specimens for any analyte (TC, 5.2%; TG, 14.7%; HDL-C, 7.2%; LDL-C, 5.4%). The average analytical variability (CVa) for each analyte, determined in quality-control pools, was; TC, 5.0%; TG, 5.2%; HDL-C, 5.8%; and LDL-C, 7.5%. Compared with standardized laboratory measurements, the desktop analyzer exhibited a significant (P < 0.001) positive bias for all analytes (average bias: TC, 5%; TG, 16%; HDL-C, 6%; and LDL-C, 2.4%). Thus, the biological variation of lipids and lipoproteins was the same in fingerstick and venous samples, and the desktop analyzer showed inherently greater analytical variability.</abstract><cop>Washington, DC</cop><pub>Am Assoc Clin Chem</pub><pmid>8969640</pmid><doi>10.1093/clinchem/42.12.2002</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical chemistry (Baltimore, Md.), 1996-12, Vol.42 (12), p.2002-2007 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Aged Biological and medical sciences Capillaries Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Female Fingers - blood supply Humans Investigative techniques, diagnostic techniques (general aspects) Lipids - blood Lipoproteins - blood Male Medical sciences Metabolic diseases Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Point-of-Care Systems Quality Control Veins |
| title | Biological variation of lipids and lipoproteins in fingerstick blood |
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