Sphingosine and psychosine, suggested inhibitors of protein kinase C, inhibit LH effects in rat luteal cells

The possible involvement of protein kinase C on luteinizing hormone (LH) effects in dispersed rat luteal cells was investigated using two substances that have been reported to be protein kinase C inhibitors, sphingosine and psychosine. Sphingosine efficiently inhibited protein kinase C activity both...

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Veröffentlicht in:	Molecular and cellular endocrinology 1988-12, Vol.60 (2), p.127-135
Hauptverfasser:	Sender Baum, Monica G., Ahrén, Kurt E.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology 8-Bromo Cyclic Adenosine Monophosphate - pharmacology Animals Biological and medical sciences Brain - drug effects Brain - metabolism Bucladesine - pharmacology Colforsin - pharmacology Corpus Luteum - metabolism Cyclic AMP Cyclic AMP - biosynthesis Cytosol - metabolism Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Luteal Cells - drug effects Luteal Cells - metabolism Luteinizing hormone Luteinizing Hormone - antagonists & inhibitors Luteinizing Hormone - pharmacology Progesterone - biosynthesis Protein kinase C Protein Kinase C - antagonists & inhibitors Psychosine Psychosine - pharmacology Rat luteal cells Rats Rats, Inbred Strains Sphingosine Sphingosine - analogs & derivatives Sphingosine - pharmacology Steroidogenesis Vertebrates: endocrinology
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