A Compartmental Model for Alveolar Clearance of Pertechnegas
The washout of an inhaled water soluble radiotracer from the lungs is a measure of alveolar integrity. Data evaluation of 99mTc-DTPA studies were previously performed mainly with monoexponential fitting with or without background subtraction. The introduction of 99mTc-pertechnegas for the assessment...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1996-12, Vol.37 (12), p.2066-2071 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Kotzerke, Jorg van den Hoff, Jorg Burchert, Wolfgang Wagner, Thomas O.F Emter, Matthias Hundeshagen, Heinz |
| description | The washout of an inhaled water soluble radiotracer from the lungs is a measure of alveolar integrity. Data evaluation of 99mTc-DTPA studies were previously performed mainly with monoexponential fitting with or without background subtraction. The introduction of 99mTc-pertechnegas for the assessment of alveolar permeability necessitates the investigation of adequate data evaluation schemes for this radiotracer.
We developed a three-compartmental model to describe 99mTc-pertechnegas kinetics after inhalation. Monoexponential fitting of the first 5 min was investigated as simplification for clinical use. Different background corrections based on blood samples or representative regions of interest were compared.
Correction of intra- and extravascular background by subtraction of calibrated curves, which are derived from blood or background areas, resulted in monoexponential washout curves. Clearance rates based on the three-compartmental model were nearly the same as those derived from a monoexponential fit after blood-activity subtraction (r = 0.96). A monoexponential analysis of the first 5 min without any background correction correlates well with the first component of the biexponential analysis (r = 0.97).
A dynamic study of more than 45 min allows quantitative determination of the transfer rate of 99mTc-pertechnegas from the alveoli into the blood using compartmental analysis. A simplified monoexponential analysis of the first 5 min allows assessment of lung clearance without any background correction. |
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We developed a three-compartmental model to describe 99mTc-pertechnegas kinetics after inhalation. Monoexponential fitting of the first 5 min was investigated as simplification for clinical use. Different background corrections based on blood samples or representative regions of interest were compared.
Correction of intra- and extravascular background by subtraction of calibrated curves, which are derived from blood or background areas, resulted in monoexponential washout curves. Clearance rates based on the three-compartmental model were nearly the same as those derived from a monoexponential fit after blood-activity subtraction (r = 0.96). A monoexponential analysis of the first 5 min without any background correction correlates well with the first component of the biexponential analysis (r = 0.97).
A dynamic study of more than 45 min allows quantitative determination of the transfer rate of 99mTc-pertechnegas from the alveoli into the blood using compartmental analysis. A simplified monoexponential analysis of the first 5 min allows assessment of lung clearance without any background correction.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 8970536</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>Administration, Inhalation ; Adult ; Aged ; Biological and medical sciences ; Contrast media. Radiopharmaceuticals ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lung - diagnostic imaging ; Male ; Medical sciences ; Middle Aged ; Models, Theoretical ; Permeability ; Pharmacology. Drug treatments ; Pulmonary Alveoli - metabolism ; Radionuclide Imaging ; Radionuclide investigations ; Respiratory system ; Sodium Pertechnetate Tc 99m - administration & dosage ; Sodium Pertechnetate Tc 99m - pharmacokinetics</subject><ispartof>The Journal of nuclear medicine (1978), 1996-12, Vol.37 (12), p.2066-2071</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright Society of Nuclear Medicine Dec 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2519926$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8970536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kotzerke, Jorg</creatorcontrib><creatorcontrib>van den Hoff, Jorg</creatorcontrib><creatorcontrib>Burchert, Wolfgang</creatorcontrib><creatorcontrib>Wagner, Thomas O.F</creatorcontrib><creatorcontrib>Emter, Matthias</creatorcontrib><creatorcontrib>Hundeshagen, Heinz</creatorcontrib><title>A Compartmental Model for Alveolar Clearance of Pertechnegas</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>The washout of an inhaled water soluble radiotracer from the lungs is a measure of alveolar integrity. Data evaluation of 99mTc-DTPA studies were previously performed mainly with monoexponential fitting with or without background subtraction. The introduction of 99mTc-pertechnegas for the assessment of alveolar permeability necessitates the investigation of adequate data evaluation schemes for this radiotracer.
We developed a three-compartmental model to describe 99mTc-pertechnegas kinetics after inhalation. Monoexponential fitting of the first 5 min was investigated as simplification for clinical use. Different background corrections based on blood samples or representative regions of interest were compared.
Correction of intra- and extravascular background by subtraction of calibrated curves, which are derived from blood or background areas, resulted in monoexponential washout curves. Clearance rates based on the three-compartmental model were nearly the same as those derived from a monoexponential fit after blood-activity subtraction (r = 0.96). A monoexponential analysis of the first 5 min without any background correction correlates well with the first component of the biexponential analysis (r = 0.97).
A dynamic study of more than 45 min allows quantitative determination of the transfer rate of 99mTc-pertechnegas from the alveoli into the blood using compartmental analysis. A simplified monoexponential analysis of the first 5 min allows assessment of lung clearance without any background correction.</description><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lung - diagnostic imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Theoretical</subject><subject>Permeability</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>Respiratory system</subject><subject>Sodium Pertechnetate Tc 99m - administration & dosage</subject><subject>Sodium Pertechnetate Tc 99m - pharmacokinetics</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkEtLxDAUhYMo4zj6E4QiIm4KeUySFtwMxReM6ELXIU1vZjqkzZi0iv_elikuXN3F-fi45xyhOeGMp1wIeYzmmAiSco75KTqLcYcxFlmWzdAsyyXmTMzR3SopfLPXoWug7bRLXnwFLrE-JCv3Bd7pkBQOdNCtgcTb5A1CB2bbwkbHc3RitYtwMd0F-ni4fy-e0vXr43OxWqcbRnGX5rpi3FAoKc4BG6BymZWSlBJAGsuMsJWFqsJLXVGDraElExTzrOSSiaEIW6Cbg3cf_GcPsVNNHQ04p1vwfVQyE5QuKRvAq3_gzvehHX5TlORUYMLyAbqcoL5soFL7UDc6_KhpkyG_nnIdjXZ2rF7HP4xykg-qAbs9YNt6s_2uA6i2N-NSo3PXNkwqQhXFQrBfVad3jA</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Kotzerke, Jorg</creator><creator>van den Hoff, Jorg</creator><creator>Burchert, Wolfgang</creator><creator>Wagner, Thomas O.F</creator><creator>Emter, Matthias</creator><creator>Hundeshagen, Heinz</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>A Compartmental Model for Alveolar Clearance of Pertechnegas</title><author>Kotzerke, Jorg ; van den Hoff, Jorg ; Burchert, Wolfgang ; Wagner, Thomas O.F ; Emter, Matthias ; Hundeshagen, Heinz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g320t-9ad35c2eb209e0ce2748b71b7ee7cf3c6fdfedd04ad2c0fc2b362058b57366673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Administration, Inhalation</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lung - diagnostic imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Theoretical</topic><topic>Permeability</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><topic>Respiratory system</topic><topic>Sodium Pertechnetate Tc 99m - administration & dosage</topic><topic>Sodium Pertechnetate Tc 99m - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kotzerke, Jorg</creatorcontrib><creatorcontrib>van den Hoff, Jorg</creatorcontrib><creatorcontrib>Burchert, Wolfgang</creatorcontrib><creatorcontrib>Wagner, Thomas O.F</creatorcontrib><creatorcontrib>Emter, Matthias</creatorcontrib><creatorcontrib>Hundeshagen, Heinz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kotzerke, Jorg</au><au>van den Hoff, Jorg</au><au>Burchert, Wolfgang</au><au>Wagner, Thomas O.F</au><au>Emter, Matthias</au><au>Hundeshagen, Heinz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Compartmental Model for Alveolar Clearance of Pertechnegas</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>37</volume><issue>12</issue><spage>2066</spage><epage>2071</epage><pages>2066-2071</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><coden>JNMEAQ</coden><abstract>The washout of an inhaled water soluble radiotracer from the lungs is a measure of alveolar integrity. Data evaluation of 99mTc-DTPA studies were previously performed mainly with monoexponential fitting with or without background subtraction. The introduction of 99mTc-pertechnegas for the assessment of alveolar permeability necessitates the investigation of adequate data evaluation schemes for this radiotracer.
We developed a three-compartmental model to describe 99mTc-pertechnegas kinetics after inhalation. Monoexponential fitting of the first 5 min was investigated as simplification for clinical use. Different background corrections based on blood samples or representative regions of interest were compared.
Correction of intra- and extravascular background by subtraction of calibrated curves, which are derived from blood or background areas, resulted in monoexponential washout curves. Clearance rates based on the three-compartmental model were nearly the same as those derived from a monoexponential fit after blood-activity subtraction (r = 0.96). A monoexponential analysis of the first 5 min without any background correction correlates well with the first component of the biexponential analysis (r = 0.97).
A dynamic study of more than 45 min allows quantitative determination of the transfer rate of 99mTc-pertechnegas from the alveoli into the blood using compartmental analysis. A simplified monoexponential analysis of the first 5 min allows assessment of lung clearance without any background correction.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>8970536</pmid><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1996-12, Vol.37 (12), p.2066-2071 |
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| subjects | Administration, Inhalation Adult Aged Biological and medical sciences Contrast media. Radiopharmaceuticals Female Humans Investigative techniques, diagnostic techniques (general aspects) Lung - diagnostic imaging Male Medical sciences Middle Aged Models, Theoretical Permeability Pharmacology. Drug treatments Pulmonary Alveoli - metabolism Radionuclide Imaging Radionuclide investigations Respiratory system Sodium Pertechnetate Tc 99m - administration & dosage Sodium Pertechnetate Tc 99m - pharmacokinetics |
| title | A Compartmental Model for Alveolar Clearance of Pertechnegas |
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