Liposomal amikacin: improved treatment of Mycobacterium avium complex infection in the beige mouse model

Disseminated Mycobacterium avium complex (MAC) infection has reached epidemic proportions and is a major cause of morbidity and mortality in AIDS patients. We have developed a liposomal preparation of amikacin, VS107, which incorporates the drug in 54–65 nm diameter unilameller phospholipid vesicles...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1996-11, Vol.38 (5), p.819-828
Hauptverfasser:	Grayson, J. B., Hersh, E. M., Dorr, R. T., Chiang, S.-M., Oka, M., Proffitt, R. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amikacin - administration & dosage Amikacin - pharmacokinetics Amikacin - therapeutic use Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Colony Count, Microbial Disease Models, Animal Dose-Response Relationship, Drug Drug Carriers Drug Evaluation, Preclinical Humans Liposomes Liver - microbiology Medical sciences Mice Mice, Inbred C57BL Mycobacterium avium Mycobacterium avium Complex - drug effects Mycobacterium avium-intracellulare Infection - drug therapy Mycobacterium avium-intracellulare Infection - microbiology Pharmacology. Drug treatments Random Allocation Spleen - microbiology
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