Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta

The oim strain of mice is one of several rodent models that exhibit an osteogenesis imperfecta (OI) phenotype. These mice have a mutation in the gene encoding α-2 chain of type I procollagen that prevents proper assembly of this propeptide with α-1 propeptides. Homozygous oim mice experience multipl...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 1996-12, Vol.19 (6), p.575-579
Hauptverfasser:	Saban, J., Zussman, M.A., Havey, R., Patwardhan, A.G., Schneider, G.B., King, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomechanical Phenomena Biomechanics Bone and Bones - injuries Bone and Bones - physiopathology Bones Diaphyses - pathology Disease Models, Animal Diseases of the osteoarticular system Female Femoral Fractures - genetics Femoral Fractures - physiopathology Heterozygote Male Malformations and congenital and or hereditary diseases involving bones. Joint deformations Medical sciences Mice Mice, Mutant Strains oim mice Osteogenesis imperfecta Osteogenesis Imperfecta - etiology Osteogenesis Imperfecta - genetics Phenotype Tibia - pathology
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