Single-Dose Oral Fluconazole in the Treatment of Vaginal Candidosis
Early studies in patients demonstrated the potential of fluconazole, as a single oral 150-mg dose, for the treatment of vaginal candidosis. Fluconazole concentrations in plasma following this dose exceed the minimum inhibitory concentration (MIC) for most strains of Candida albicans (0.4-0.8 mg/l) f...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 1988, Vol.544 (1), p.561-563 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | BRAMMER, KEITH W. FECZKO, JOSEPH M. |
| description | Early studies in patients demonstrated the potential of fluconazole, as a single oral 150-mg dose, for the treatment of vaginal candidosis. Fluconazole concentrations in plasma following this dose exceed the minimum inhibitory concentration (MIC) for most strains of Candida albicans (0.4-0.8 mg/l) for 3-4 days. This paper presents the results of two multicenter clinical studies in which the efficacy of this fluconazole dosage was compared with 1) intravaginal clotrimazole (200 mg, in a standard local treatment for 3 consecutive days) and 2) oral ketoconazole (200 mg, twice a day for 5 consecutive days) in the treatment of patients with acute vaginal candidosis. |
| doi_str_mv | 10.1111/j.1749-6632.1988.tb40452.x |
| format | Article |
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This paper presents the results of two multicenter clinical studies in which the efficacy of this fluconazole dosage was compared with 1) intravaginal clotrimazole (200 mg, in a standard local treatment for 3 consecutive days) and 2) oral ketoconazole (200 mg, twice a day for 5 consecutive days) in the treatment of patients with acute vaginal candidosis.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/j.1749-6632.1988.tb40452.x</identifier><identifier>PMID: 2850756</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Administration, Topical ; Antifungal Agents - therapeutic use ; Candidiasis, Vulvovaginal - drug therapy ; Clinical Trials as Topic ; Double-Blind Method ; Drug Administration Schedule ; Female ; Fluconazole ; Humans ; Ketoconazole - therapeutic use ; Triazoles - administration & dosage ; Triazoles - therapeutic use</subject><ispartof>Annals of the New York Academy of Sciences, 1988, Vol.544 (1), p.561-563</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3541-cf2f2b1b89e85b2d3e67066572665564abceb2c8a71c71e8d24057a318a6f4623</citedby><cites>FETCH-LOGICAL-c3541-cf2f2b1b89e85b2d3e67066572665564abceb2c8a71c71e8d24057a318a6f4623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1749-6632.1988.tb40452.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1749-6632.1988.tb40452.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,1411,4010,4036,4037,23909,23910,25118,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2850756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>St. Georgiev, V</contributor><creatorcontrib>BRAMMER, KEITH W.</creatorcontrib><creatorcontrib>FECZKO, JOSEPH M.</creatorcontrib><title>Single-Dose Oral Fluconazole in the Treatment of Vaginal Candidosis</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>Early studies in patients demonstrated the potential of fluconazole, as a single oral 150-mg dose, for the treatment of vaginal candidosis. 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| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 1988, Vol.544 (1), p.561-563 |
| issn | 0077-8923 1749-6632 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78620909 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Administration, Oral Administration, Topical Antifungal Agents - therapeutic use Candidiasis, Vulvovaginal - drug therapy Clinical Trials as Topic Double-Blind Method Drug Administration Schedule Female Fluconazole Humans Ketoconazole - therapeutic use Triazoles - administration & dosage Triazoles - therapeutic use |
| title | Single-Dose Oral Fluconazole in the Treatment of Vaginal Candidosis |
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