Characterisation of [3H]MK-801 Binding and its Cooperative Modulation by PIG Brain Membranes

Abstract Cooperative modulation of [3H]MK-801 binding to extensively washed pig cortical brain membranes in the presence of various concentrations of L-glutamate, glycine, spermine, CPP and DCKA was evaluated in association experiments. In saturation experiments [3H]MK-801 labelled a homogeneous pop...

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Veröffentlicht in:	Journal of receptors and signal transduction 1996-01, Vol.16 (5-6), p.297-313
Hauptverfasser:	Höfner, G., Wanner, K. Th
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Cerebral Cortex - metabolism Dizocilpine Maleate - metabolism Excitatory Amino Acid Antagonists - metabolism Glutamic Acid - pharmacology Glycine - pharmacology Kinetics Kynurenic Acid - analogs & derivatives Kynurenic Acid - metabolism Piperazines - metabolism Piperidines - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Spermine - pharmacology Swine
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