In vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of D5 receptors in rats

To characterize the membrane pathway by which the cocaine-sensitive dopamine transporter (DAT) modulates progesterone receptor activation, steroid-dependent behavior lordosis was used in estrogen-primed ovariectomized Sprague-Dawley rats with stereotaxic implanted third ventricle cannulas. Lordosis...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 1996-12, Vol.10 (12), p.1595-1604
Hauptverfasser:	Apostolakis, E M, Garai, J, Clark, J H, O'Malley, B W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antisense Elements (Genetics) - genetics Antisense Elements (Genetics) - metabolism Antisense Elements (Genetics) - pharmacology Behavior, Animal - drug effects Carrier Proteins - drug effects Carrier Proteins - metabolism Central Nervous System - drug effects Central Nervous System - metabolism Cocaine - analogs & derivatives Cocaine - pharmacology Dopamine Plasma Membrane Transport Proteins Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Female Hormone Antagonists - pharmacology Membrane Glycoproteins Membrane Transport Proteins Mifepristone - pharmacology Narcotics - pharmacology Nerve Tissue Proteins Neurons - drug effects Neurons - metabolism Ovariectomy Posture Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - drug effects Receptors, Dopamine D1 - genetics Receptors, Dopamine D1 - metabolism Receptors, Dopamine D5 Receptors, Progesterone - drug effects Receptors, Progesterone - metabolism Sexual Behavior, Animal - drug effects Steroids - physiology Ventromedial Hypothalamic Nucleus - drug effects Ventromedial Hypothalamic Nucleus - metabolism
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