Effect of RO 23-9424, cefotaxime and fleroxacin on functions of human polymorphonuclear cells and cytokine production by human monocytes

The way in which an antibiotic interacts with host defences could influence the clinical outcome of many infectious diseases. The impact of RO 23-9424, a novel dual-action and extended-spectrum antibiotic, was studied on several functions of human polymorphonuclear neutrophils (PMNs). A significant...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1996-11, Vol.38 (5), p.799-807
Hauptverfasser:	Berlinghieri, M. C., Foti, F., Barreca, G. S., Focà, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefotaxime - analogs & derivatives Cefotaxime - pharmacology Cephalosporins - pharmacology Chemotaxis, Leukocyte - drug effects Dose-Response Relationship, Drug Fleroxacin - analogs & derivatives Fleroxacin - pharmacology Fluoroquinolones Humans Interleukin-1 - metabolism Interleukin-8 - metabolism Lipopolysaccharides - pharmacology Medical sciences Monocytes - drug effects Monocytes - metabolism Neutrophils - drug effects Neutrophils - physiology Phagocytosis - drug effects Pharmacology. Drug treatments Superoxides - metabolism Tumor Necrosis Factor-alpha - metabolism
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