Human Telomerase Inhibition by 7-Deaza-2‘-deoxypurine Nucleoside Triphosphates

Telomeres play an important role in chromosome organization and stability. Human telomerase is a terminal transferase that adds TTAGGG units onto the telomere end. In general, telomerase activity is not detected in normal somatic cells but is present in immortalized cells. Consequently, telomerase m...

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Veröffentlicht in:	Biochemistry (Easton) 1996-12, Vol.35 (49), p.15611-15617
Hauptverfasser:	Fletcher, Terace M, Salazar, Miguel, Chen, Shih-Fong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Deoxyadenine Nucleotides - metabolism Deoxyadenine Nucleotides - pharmacology Deoxyguanine Nucleotides - metabolism Deoxyguanine Nucleotides - pharmacology DNA Primers - chemistry DNA Primers - metabolism Humans Kidney - embryology Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Purine Nucleotides - pharmacology Ribonuclease, Pancreatic - metabolism Telomerase - antagonists & inhibitors Telomerase - isolation & purification Telomerase - metabolism
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