Ten years after: reclassification of steroid-responsive genes
Although several hundred genes are directly or indirectly regulated by steroid hormones, significant gaps exist in our understanding of the relevant mechanisms, particularly for those genes that do not directly bind intracellular receptors or that exhibit delayed changes in transcription rates upon...
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| Veröffentlicht in: | Molecular endocrinology (Baltimore, Md.) Md.), 1996-12, Vol.10 (12), p.1489-1495 |
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| container_end_page | 1495 |
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| container_issue | 12 |
| container_start_page | 1489 |
| container_title | Molecular endocrinology (Baltimore, Md.) |
| container_volume | 10 |
| creator | Dean, D M Sanders, M M |
| description | Although several hundred genes are directly or indirectly regulated by steroid hormones, significant gaps exist in our understanding of the relevant mechanisms, particularly for those genes that do not directly bind intracellular receptors or that exhibit delayed changes in transcription rates upon receptor binding. To assist in defining the mechanism of action of steroid hormones, we are proposing that a standard nomenclature be adopted for classifying steroid-responsive genes, based upon whether the receptors directly bind to the target genes and the kinetics of the response. Three categories are proposed: primary response genes, delayed primary response genes, and secondary response genes. |
| doi_str_mv | 10.1210/me.10.12.1489 |
| format | Article |
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To assist in defining the mechanism of action of steroid hormones, we are proposing that a standard nomenclature be adopted for classifying steroid-responsive genes, based upon whether the receptors directly bind to the target genes and the kinetics of the response. 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Three categories are proposed: primary response genes, delayed primary response genes, and secondary response genes.</description><subject>Animals</subject><subject>Arginase - genetics</subject><subject>Arginase - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Osteocalcin - genetics</subject><subject>Osteocalcin - metabolism</subject><subject>Ovalbumin - genetics</subject><subject>Ovalbumin - metabolism</subject><subject>Receptors, Steroid - classification</subject><subject>Receptors, Steroid - genetics</subject><subject>Receptors, Steroid - metabolism</subject><subject>Tryptophan Oxygenase - genetics</subject><subject>Tryptophan Oxygenase - metabolism</subject><subject>Vitellogenins - genetics</subject><issn>0888-8809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL9PwzAQhT2ASimMjEiZ2FJ8sZPYSAyo4pdUiaXMkeOckVESF1-C1P-elFasTPek-_T09DF2BXwJGfDbDpe_cQlS6RM250qpVCmuz9g50SfnIHMFMzZTuoAs13N2v8E-2aGJlBg3YLxLItrWEHnnrRl86JPgEpo-wTdpRNqGnvw3Jh_YI12wU2dawsvjXbD3p8fN6iVdvz2_rh7WqRUqH1IhXKGnSSgyjiANWG6MzVWT18rZRudSZbKZQsFz4Jl0Bow0GkrnBJZ1LRbs5tC7jeFrRBqqzpPFtjU9hpGqUhVQqpL_C0LBJWieTWB6AG0MRBFdtY2-M3FXAa_2LqsOD7Hau5z462PxWHfY_NFHkeIHKGdxGQ</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Dean, D M</creator><creator>Sanders, M M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Ten years after: reclassification of steroid-responsive genes</title><author>Dean, D M ; Sanders, M M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-33f69148e320e14a1c0aac58d5b8fcd954824dcd96051024fa1a4a917ff3e7bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Arginase - genetics</topic><topic>Arginase - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Osteocalcin - genetics</topic><topic>Osteocalcin - metabolism</topic><topic>Ovalbumin - genetics</topic><topic>Ovalbumin - metabolism</topic><topic>Receptors, Steroid - classification</topic><topic>Receptors, Steroid - genetics</topic><topic>Receptors, Steroid - metabolism</topic><topic>Tryptophan Oxygenase - genetics</topic><topic>Tryptophan Oxygenase - metabolism</topic><topic>Vitellogenins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dean, D M</creatorcontrib><creatorcontrib>Sanders, M M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular endocrinology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dean, D M</au><au>Sanders, M M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ten years after: reclassification of steroid-responsive genes</atitle><jtitle>Molecular endocrinology (Baltimore, Md.)</jtitle><addtitle>Mol Endocrinol</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>10</volume><issue>12</issue><spage>1489</spage><epage>1495</epage><pages>1489-1495</pages><issn>0888-8809</issn><abstract>Although several hundred genes are directly or indirectly regulated by steroid hormones, significant gaps exist in our understanding of the relevant mechanisms, particularly for those genes that do not directly bind intracellular receptors or that exhibit delayed changes in transcription rates upon receptor binding. 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| fulltext | fulltext |
| identifier | ISSN: 0888-8809 |
| ispartof | Molecular endocrinology (Baltimore, Md.), 1996-12, Vol.10 (12), p.1489-1495 |
| issn | 0888-8809 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78617870 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Arginase - genetics Arginase - metabolism Gene Expression Regulation Humans Models, Biological Osteocalcin - genetics Osteocalcin - metabolism Ovalbumin - genetics Ovalbumin - metabolism Receptors, Steroid - classification Receptors, Steroid - genetics Receptors, Steroid - metabolism Tryptophan Oxygenase - genetics Tryptophan Oxygenase - metabolism Vitellogenins - genetics |
| title | Ten years after: reclassification of steroid-responsive genes |
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