GM phenotypes influence the concentrations of the four subclasses of immunoglobulin G in normal human serum

The concentrations of the four subclasses of IgG were measured in the sera of 116 adult healthy Caucasian blood donors. Sera were also typed for nine GM determinants. All IgG subclass concentrations were significantly associated with GM phenotypes. The concentration of IgGl was lower in subjects wit...

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Veröffentlicht in:	Human immunology 1996-12, Vol.51 (2), p.99-102
Hauptverfasser:	Pandey, Janardan P., French, Martyn A.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Female Humans Immunoglobulin G - blood Immunoglobulin Gm Allotypes - blood Immunoglobulin Isotypes - blood Male Middle Aged Phenotype
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container_title	Human immunology
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creator	Pandey, Janardan P. French, Martyn A.H.
description	The concentrations of the four subclasses of IgG were measured in the sera of 116 adult healthy Caucasian blood donors. Sera were also typed for nine GM determinants. All IgG subclass concentrations were significantly associated with GM phenotypes. The concentration of IgGl was lower in subjects with the GM 3 23 5,13 phenotype as compared with those who lacked this phenotype. Increased levels of IgG2 and IgG4 were associated with GM 1,2,3,17 23 5,13,21 and GM 1,3,17 23 5,13,21, respectively. IgG3 concentrations were the lowest for subjects with the GM 1,2,17 21 phenotype, intermediate for GM 1,3,17 5,13,21, and the highest in subjects with GM 3 23 5,13.
doi_str_mv	10.1016/S0198-8859(96)00205-4
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Sera were also typed for nine GM determinants. All IgG subclass concentrations were significantly associated with GM phenotypes. The concentration of IgGl was lower in subjects with the GM 3 23 5,13 phenotype as compared with those who lacked this phenotype. Increased levels of IgG2 and IgG4 were associated with GM 1,2,3,17 23 5,13,21 and GM 1,3,17 23 5,13,21, respectively. 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Sera were also typed for nine GM determinants. All IgG subclass concentrations were significantly associated with GM phenotypes. The concentration of IgGl was lower in subjects with the GM 3 23 5,13 phenotype as compared with those who lacked this phenotype. Increased levels of IgG2 and IgG4 were associated with GM 1,2,3,17 23 5,13,21 and GM 1,3,17 23 5,13,21, respectively. IgG3 concentrations were the lowest for subjects with the GM 1,2,17 21 phenotype, intermediate for GM 1,3,17 5,13,21, and the highest in subjects with GM 3 23 5,13.</description><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin Gm Allotypes - blood</subject><subject>Immunoglobulin Isotypes - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phenotype</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAUtBCobAs_oZJPCA4p7zmJP05VtWq3lVpxAM6W4zisIbEXO0bqvyf7oV57ek9vZt5IM4RcIlwhIP_6HVDJSspWfVb8CwCDtmrekBVKoSpEzt-S1QvlPTnP-TcACBDNGTmTioNCtiJ_Nk90t3Uhzs87l6kPw1hcsI7OW0dtXLYwJzP7GDKNw-E6xJJoLp0dTc7ucPbTVEL8NcaujD7QzfKHhpgmM9JtmUyg2aUyfSDvBjNm9_E0L8jPu9sf6_vq8dvmYX3zWNmmqecKWQ89DFYwENbKRramNhyZ6iTWLchu4JK1KDrTik5JFKh6aWxnuTECGltfkE_Hv7sU_xaXZz35bN04muBiyVpIjpyx-lUitoopycRCbI9Em2LOyQ16l_xk0rNG0Ps29KENvY9aK64Pbehm0V2eDEo3uf5FdYp_wa-PuFvi-Odd0tn6ffy9T87Ouo_-FYf_qAuaug</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Pandey, Janardan P.</creator><creator>French, Martyn A.H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>GM phenotypes influence the concentrations of the four subclasses of immunoglobulin G in normal human serum</title><author>Pandey, Janardan P. ; French, Martyn A.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-12d0d0fc7207cc8485a3a6129b813508bf682517ba57b981719d8acbc6aa704c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin Gm Allotypes - blood</topic><topic>Immunoglobulin Isotypes - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phenotype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pandey, Janardan P.</creatorcontrib><creatorcontrib>French, Martyn A.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pandey, Janardan P.</au><au>French, Martyn A.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GM phenotypes influence the concentrations of the four subclasses of immunoglobulin G in normal human serum</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>51</volume><issue>2</issue><spage>99</spage><epage>102</epage><pages>99-102</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>The concentrations of the four subclasses of IgG were measured in the sera of 116 adult healthy Caucasian blood donors. 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subjects	Adult Female Humans Immunoglobulin G - blood Immunoglobulin Gm Allotypes - blood Immunoglobulin Isotypes - blood Male Middle Aged Phenotype
title	GM phenotypes influence the concentrations of the four subclasses of immunoglobulin G in normal human serum
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