Heart Transplantation in Patients 70 Years of Age and Older: Initial Experience
Background. Heart transplantation has become a highly successful therapeutic option for patients with end-stage cardiomyopathy. Consequently, the criteria for patient selection, particularly regarding recipients' upper age limits, have been expanded, with an increasing number of people older th...
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| Veröffentlicht in: | The Annals of thoracic surgery 1996-12, Vol.62 (6), p.1731-1736 |
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| container_issue | 6 |
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| container_title | The Annals of thoracic surgery |
| container_volume | 62 |
| creator | Blanche, Carlos Matloff, Jack M Denton, Timothy A Czer, Lawrence S.C Fishbein, Michael C Takkenberg, Johanna J.M Trento, Alfredo |
| description | Background. Heart transplantation has become a highly successful therapeutic option for patients with end-stage cardiomyopathy. Consequently, the criteria for patient selection, particularly regarding recipients' upper age limits, have been expanded, with an increasing number of people older than 60 years of age now undergoing transplantation.
Methods. A retrospective analysis of 6 patients 70 years of age and older who underwent heart transplantation was done; their clinical courses and outcomes were compared with those of younger patients, with a special emphasis on their posttransplantation quality of life.
Results. All 6 patients are alive and clinically well at a mean follow-up of 12 months. No age-related complications have been observed, and their quality of life is excellent. There has been a very low incidence of rejection, as well as few episodes of rejection.
Conclusions. Heart transplantation in selected people 70 years of age and older can be performed successfully with a morbidity comparable to that seen in younger patients and excellent short-term survival. This initial experience is encouraging, but further studies and long-term follow-up are needed to validate the more routine application of this therapy. |
| doi_str_mv | 10.1016/S0003-4975(96)00489-4 |
| format | Article |
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Methods. A retrospective analysis of 6 patients 70 years of age and older who underwent heart transplantation was done; their clinical courses and outcomes were compared with those of younger patients, with a special emphasis on their posttransplantation quality of life.
Results. All 6 patients are alive and clinically well at a mean follow-up of 12 months. No age-related complications have been observed, and their quality of life is excellent. There has been a very low incidence of rejection, as well as few episodes of rejection.
Conclusions. Heart transplantation in selected people 70 years of age and older can be performed successfully with a morbidity comparable to that seen in younger patients and excellent short-term survival. This initial experience is encouraging, but further studies and long-term follow-up are needed to validate the more routine application of this therapy.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(96)00489-4</identifier><identifier>PMID: 8957378</identifier><identifier>CODEN: ATHSAK</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age Factors ; Aged ; Biological and medical sciences ; Female ; Graft Rejection ; Heart Transplantation - mortality ; Humans ; Length of Stay ; Male ; Medical sciences ; Postoperative Complications ; Quality of Life ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Survival Rate</subject><ispartof>The Annals of thoracic surgery, 1996-12, Vol.62 (6), p.1731-1736</ispartof><rights>1996 The Society of Thoracic Surgeons</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-cd36875eccabfaa1821647195e840495a03ac60062d4b06836711e3d70ba407a3</citedby><cites>FETCH-LOGICAL-c472t-cd36875eccabfaa1821647195e840495a03ac60062d4b06836711e3d70ba407a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0003-4975(96)00489-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2510740$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8957378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanche, Carlos</creatorcontrib><creatorcontrib>Matloff, Jack M</creatorcontrib><creatorcontrib>Denton, Timothy A</creatorcontrib><creatorcontrib>Czer, Lawrence S.C</creatorcontrib><creatorcontrib>Fishbein, Michael C</creatorcontrib><creatorcontrib>Takkenberg, Johanna J.M</creatorcontrib><creatorcontrib>Trento, Alfredo</creatorcontrib><title>Heart Transplantation in Patients 70 Years of Age and Older: Initial Experience</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background. Heart transplantation has become a highly successful therapeutic option for patients with end-stage cardiomyopathy. Consequently, the criteria for patient selection, particularly regarding recipients' upper age limits, have been expanded, with an increasing number of people older than 60 years of age now undergoing transplantation.
Methods. A retrospective analysis of 6 patients 70 years of age and older who underwent heart transplantation was done; their clinical courses and outcomes were compared with those of younger patients, with a special emphasis on their posttransplantation quality of life.
Results. All 6 patients are alive and clinically well at a mean follow-up of 12 months. No age-related complications have been observed, and their quality of life is excellent. There has been a very low incidence of rejection, as well as few episodes of rejection.
Conclusions. Heart transplantation in selected people 70 years of age and older can be performed successfully with a morbidity comparable to that seen in younger patients and excellent short-term survival. This initial experience is encouraging, but further studies and long-term follow-up are needed to validate the more routine application of this therapy.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>Heart Transplantation - mortality</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Postoperative Complications</subject><subject>Quality of Life</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Survival Rate</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BCEHET1UJ20-Wi8i4hcIK6gHT2E2nUqk265JV_TfG3eXvXrKhPeZmeRh7FDAmQChz58BoMhkZdRJpU8BZFllcoONhFJ5pnNVbbLRGtlhuzF-pGue4m22XVbKFKYcsfE9YRj4S8AuzlrsBhx833Hf8adUUTdEboC_JSjyvuFX78Sxq_m4rSlc8IfODx5bfvM9o5BoR_tsq8E20sHq3GOvtzcv1_fZ4_ju4frqMXPS5EPm6kKXRpFzOGkQRZkLLY2oFJUSZKUQCnQaQOe1nIAuC22EoKI2MEEJBos9drycOwv955ziYKc-OmrTF6ifR2tKLTSIIoFqCbrQxxiosbPgpxh-rAD7J9IuRNo_S7bSdiHSytR3uFown0ypXnetzKX8aJVjdNg2SaDzcY3lSoCRkLDLJUZJxpenYKNbiKp9IDfYuvf_POQXqLSNOQ</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Blanche, Carlos</creator><creator>Matloff, Jack M</creator><creator>Denton, Timothy A</creator><creator>Czer, Lawrence S.C</creator><creator>Fishbein, Michael C</creator><creator>Takkenberg, Johanna J.M</creator><creator>Trento, Alfredo</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Heart Transplantation in Patients 70 Years of Age and Older: Initial Experience</title><author>Blanche, Carlos ; Matloff, Jack M ; Denton, Timothy A ; Czer, Lawrence S.C ; Fishbein, Michael C ; Takkenberg, Johanna J.M ; Trento, Alfredo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-cd36875eccabfaa1821647195e840495a03ac60062d4b06836711e3d70ba407a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Graft Rejection</topic><topic>Heart Transplantation - mortality</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Postoperative Complications</topic><topic>Quality of Life</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blanche, Carlos</creatorcontrib><creatorcontrib>Matloff, Jack M</creatorcontrib><creatorcontrib>Denton, Timothy A</creatorcontrib><creatorcontrib>Czer, Lawrence S.C</creatorcontrib><creatorcontrib>Fishbein, Michael C</creatorcontrib><creatorcontrib>Takkenberg, Johanna J.M</creatorcontrib><creatorcontrib>Trento, Alfredo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blanche, Carlos</au><au>Matloff, Jack M</au><au>Denton, Timothy A</au><au>Czer, Lawrence S.C</au><au>Fishbein, Michael C</au><au>Takkenberg, Johanna J.M</au><au>Trento, Alfredo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart Transplantation in Patients 70 Years of Age and Older: Initial Experience</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>62</volume><issue>6</issue><spage>1731</spage><epage>1736</epage><pages>1731-1736</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><coden>ATHSAK</coden><abstract>Background. Heart transplantation has become a highly successful therapeutic option for patients with end-stage cardiomyopathy. Consequently, the criteria for patient selection, particularly regarding recipients' upper age limits, have been expanded, with an increasing number of people older than 60 years of age now undergoing transplantation.
Methods. A retrospective analysis of 6 patients 70 years of age and older who underwent heart transplantation was done; their clinical courses and outcomes were compared with those of younger patients, with a special emphasis on their posttransplantation quality of life.
Results. All 6 patients are alive and clinically well at a mean follow-up of 12 months. No age-related complications have been observed, and their quality of life is excellent. There has been a very low incidence of rejection, as well as few episodes of rejection.
Conclusions. Heart transplantation in selected people 70 years of age and older can be performed successfully with a morbidity comparable to that seen in younger patients and excellent short-term survival. This initial experience is encouraging, but further studies and long-term follow-up are needed to validate the more routine application of this therapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8957378</pmid><doi>10.1016/S0003-4975(96)00489-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Age Factors Aged Biological and medical sciences Female Graft Rejection Heart Transplantation - mortality Humans Length of Stay Male Medical sciences Postoperative Complications Quality of Life Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Survival Rate |
| title | Heart Transplantation in Patients 70 Years of Age and Older: Initial Experience |
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