Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

A new series of hitherto unknown 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) phosphonodiester derivatives incorporating carboxyesterase-labile S-acyl-2-thioethyl (SATE) moieties as transient phosphonate-protecting groups was prepared in an attempt to increase the oral bioavailability of the antivira...

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Veröffentlicht in:	Journal of medicinal chemistry 1996-12, Vol.39 (25), p.4958-4965
Hauptverfasser:	Benzaria, Samira, Pélicano, Hélène, Johnson, Richard, Maury, Georges, Imbach, Jean-Louis, Aubertin, Anne-Marie, Obert, Georges, Gosselin, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - chemical synthesis Adenine - chemistry Adenine - pharmacology Administration, Oral AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - chemistry Antiviral Agents - pharmacokinetics Biological and medical sciences Biological Availability Cell Line Drug Stability Herpesvirus 1, Human - drug effects Humans Magnetic Resonance Spectroscopy Medical sciences Organophosphonates Pharmacology. Drug treatments Prodrugs - administration & dosage Prodrugs - chemistry Prodrugs - pharmacokinetics Spectrometry, Mass, Fast Atom Bombardment
Online-Zugang:	Volltext
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