The thiazolidinedione insulin sensitiser, BRL 49653, increases the expression of PPAR-gamma and aP2 in adipose tissue of high-fat-fed rats

The effects of the thiazolidinedione insulin sensitiser BRL 49653 on plasma leptin concentrations and on epididymal fat OB, PPAR-gamma and aP2 mRNA expression were examined in high-fat-fed and high-carbohydrate-fed adult Wistar rats. Diets were given for 4 weeks, with BRL 49653 (10 micromol/kg/day)...

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Veröffentlicht in:	Biochemical and biophysical research communications 1996-12, Vol.229 (3), p.752-757
Hauptverfasser:	Pearson, S L, Cawthorne, M A, Clapham, J C, Dunmore, S J, Holmes, S D, Moore, G B, Smith, S A, Tadayyon, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Animals Carrier Proteins - biosynthesis Dietary Fats - administration & dosage Fatty Acid-Binding Protein 7 Fatty Acid-Binding Proteins Hypoglycemic Agents - pharmacology Male Myelin P2 Protein - biosynthesis Neoplasm Proteins Nerve Tissue Proteins Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear - biosynthesis RNA, Messenger - analysis Thiazoles - pharmacology Thiazolidinediones Transcription Factors - biosynthesis
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Zusammenfassung:	The effects of the thiazolidinedione insulin sensitiser BRL 49653 on plasma leptin concentrations and on epididymal fat OB, PPAR-gamma and aP2 mRNA expression were examined in high-fat-fed and high-carbohydrate-fed adult Wistar rats. Diets were given for 4 weeks, with BRL 49653 (10 micromol/kg/day) administered by oral gavage for the last 4 days. Treatment with BRL 49653 reduced plasma leptin concentrations in high-fat-fed rats from 2.34 +/- 0.19 (n=9) to 1.42 +/- 0.09 (n=9) ng/ml (p
ISSN:	0006-291X
DOI:	10.1006/bbrc.1996.1876