Mice Lacking the 65 kDa Isoform of Glutamic Acid Decarboxylase (GAD65) Maintain Normal Levels of GAD67 and GABA in Their Brains but Are Susceptible to Seizures

The gene encoding of the 65 kDa isoform of the γ-aminobutyric acid (GABA)-synthesizing enzyme, glutamic acid decarboxylase (GAD), GAD65, was targeted in mice by homologous recombination. Viable GAD65 −/− mice were obtained with the expected mendelian frequency and displayed no gross morphological de...

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Veröffentlicht in:	Biochemical and biophysical research communications 1996-12, Vol.229 (3), p.891-895
Hauptverfasser:	Asada, Hideo, Kawamura, Yuuki, Maruyama, Kei, Kume, Hideaki, Ding, Ri-gao, Ji, Feng Yun, Kanbara, Nobuko, Kuzume, Hiroko, Sanbo, Makoto, Yagi, Takeshi, Obata, Kunihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - physiology gamma-Aminobutyric Acid - physiology Glutamate Decarboxylase - deficiency Isoenzymes - deficiency Locomotion - physiology Mice Mice, Mutant Strains Seizures - metabolism
Online-Zugang:	Volltext
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