Second primary lung cancer in Flanders: frequency, clinical presentation, treatment and prognosis
Patient and tumour characteristics of 23 patients presenting with a second primary lung cancer were analysed and compared with 534 patients with radically resected stage 1 non-small cell lung cancer (NSCLC). None of these characteristics is associated with a higher occurrence rate for second primary...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 1996-11, Vol.15 (3), p.281-295 |
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| container_title | Lung cancer (Amsterdam, Netherlands) |
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| creator | Van Meerbeeck, J. Weyler, J. Thibaut, A. Vansteenkiste, J. Aumann, J. Deneffe, G. Galdermans, D. Haelterman, M. Joos, G. Noppen, M. Pinson, P. Tasson, J. Van Den Eeckhout, A. Uydebrouck, M. |
| description | Patient and tumour characteristics of 23 patients presenting with a second primary lung cancer were analysed and compared with 534 patients with radically resected stage 1 non-small cell lung cancer (NSCLC). None of these characteristics is associated with a higher occurrence rate for second primary lung cancer. Prognosis in the latter patients is significantly worse than after resection of a ‘solitary’ NSCLC: the median survival time (MST) after resection of the first tumour is 50 months; after diagnosis of the second tumour only 14 months. Surgically retreated patients have a prognosis that is similar to that after resection of a ‘solitary’ NSCLC. No separate independent prognostic factors responsible for this surivival difference could be isolated. Squamous histology and central location are associated with a longer recurrence free survival time. We conclude that the occurrence of a second primary lung cancer can not be predicted based on patient or tumour characteristics and that only surgical retreatment offers a chance of long survival in these patients. |
| doi_str_mv | 10.1016/0169-5002(95)00593-5 |
| format | Article |
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None of these characteristics is associated with a higher occurrence rate for second primary lung cancer. Prognosis in the latter patients is significantly worse than after resection of a ‘solitary’ NSCLC: the median survival time (MST) after resection of the first tumour is 50 months; after diagnosis of the second tumour only 14 months. Surgically retreated patients have a prognosis that is similar to that after resection of a ‘solitary’ NSCLC. No separate independent prognostic factors responsible for this surivival difference could be isolated. Squamous histology and central location are associated with a longer recurrence free survival time. We conclude that the occurrence of a second primary lung cancer can not be predicted based on patient or tumour characteristics and that only surgical retreatment offers a chance of long survival in these patients.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/0169-5002(95)00593-5</identifier><identifier>PMID: 8959675</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Belgium - epidemiology ; Biopsy ; Carcinoma, Non-Small-Cell Lung - epidemiology ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - surgery ; Female ; Follow-Up Studies ; Humans ; Incidence ; Lung Neoplasms - epidemiology ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Male ; Middle Aged ; Neoplasm Staging ; Neoplasms, Second Primary - epidemiology ; Neoplasms, Second Primary - pathology ; Neoplasms, Second Primary - surgery ; Non-small cell lung cancer ; Prognosis ; Prospective Studies ; Recurrence ; Resection ; Second primary lung cancer ; Survival ; Survival Rate</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 1996-11, Vol.15 (3), p.281-295</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-e3016d6a5a7dd1f8de589c3eeb6600558cc52c2f7b1b287a4fe050ca9a17f20f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0169-5002(95)00593-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8959675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Meerbeeck, J.</creatorcontrib><creatorcontrib>Weyler, J.</creatorcontrib><creatorcontrib>Thibaut, A.</creatorcontrib><creatorcontrib>Vansteenkiste, J.</creatorcontrib><creatorcontrib>Aumann, J.</creatorcontrib><creatorcontrib>Deneffe, G.</creatorcontrib><creatorcontrib>Galdermans, D.</creatorcontrib><creatorcontrib>Haelterman, M.</creatorcontrib><creatorcontrib>Joos, G.</creatorcontrib><creatorcontrib>Noppen, M.</creatorcontrib><creatorcontrib>Pinson, P.</creatorcontrib><creatorcontrib>Tasson, J.</creatorcontrib><creatorcontrib>Van Den Eeckhout, A.</creatorcontrib><creatorcontrib>Uydebrouck, M.</creatorcontrib><title>Second primary lung cancer in Flanders: frequency, clinical presentation, treatment and prognosis</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>Patient and tumour characteristics of 23 patients presenting with a second primary lung cancer were analysed and compared with 534 patients with radically resected stage 1 non-small cell lung cancer (NSCLC). None of these characteristics is associated with a higher occurrence rate for second primary lung cancer. Prognosis in the latter patients is significantly worse than after resection of a ‘solitary’ NSCLC: the median survival time (MST) after resection of the first tumour is 50 months; after diagnosis of the second tumour only 14 months. Surgically retreated patients have a prognosis that is similar to that after resection of a ‘solitary’ NSCLC. No separate independent prognostic factors responsible for this surivival difference could be isolated. Squamous histology and central location are associated with a longer recurrence free survival time. We conclude that the occurrence of a second primary lung cancer can not be predicted based on patient or tumour characteristics and that only surgical retreatment offers a chance of long survival in these patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Belgium - epidemiology</subject><subject>Biopsy</subject><subject>Carcinoma, Non-Small-Cell Lung - epidemiology</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Second Primary - epidemiology</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Neoplasms, Second Primary - surgery</subject><subject>Non-small cell lung cancer</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Resection</subject><subject>Second primary lung cancer</subject><subject>Survival</subject><subject>Survival Rate</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotVa_gUJOotDVZLfZJB4EKf6Dggf1HLLJbIlss5rsCv32pu3So4cwhHlvZt4PoXNKbiih5W16MmOE5FeSXRPCZJGxAzSmgueZKIr8EI33kmN0EuMXIZRTIkdoJCSTJWdjpN_BtN7i7-BWOqxx0_slNtobCNh5_NRobyHEO1wH-OnBm_UUm8Z5Z3STTBDBd7pzrZ_iLoDuVumP9XZgu_RtdPEUHdW6iXA21An6fHr8mL9ki7fn1_nDIjMF410GRTrWlpppbi2thQUmpCkAqrJM4ZgwhuUmr3lFq1xwPauBMGK01JTXOamLCbrczU2b06WxUysXDTQpAbR9VFyUlLG8SMLZTmhCG2OAWg3hFSVqQ1ZtsKkNNiWZ2pJVLNkuhvl9tQK7Nw0oU_9-14cU8tdBUNG4BAysC2A6ZVv3_4I_houJUQ</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Van Meerbeeck, J.</creator><creator>Weyler, J.</creator><creator>Thibaut, A.</creator><creator>Vansteenkiste, J.</creator><creator>Aumann, J.</creator><creator>Deneffe, G.</creator><creator>Galdermans, D.</creator><creator>Haelterman, M.</creator><creator>Joos, G.</creator><creator>Noppen, M.</creator><creator>Pinson, P.</creator><creator>Tasson, J.</creator><creator>Van Den Eeckhout, A.</creator><creator>Uydebrouck, M.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Second primary lung cancer in Flanders: frequency, clinical presentation, treatment and prognosis</title><author>Van Meerbeeck, J. ; Weyler, J. ; Thibaut, A. ; Vansteenkiste, J. ; Aumann, J. ; Deneffe, G. ; Galdermans, D. ; Haelterman, M. ; Joos, G. ; Noppen, M. ; Pinson, P. ; Tasson, J. ; Van Den Eeckhout, A. ; Uydebrouck, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-e3016d6a5a7dd1f8de589c3eeb6600558cc52c2f7b1b287a4fe050ca9a17f20f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Belgium - epidemiology</topic><topic>Biopsy</topic><topic>Carcinoma, Non-Small-Cell Lung - epidemiology</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Second Primary - epidemiology</topic><topic>Neoplasms, Second Primary - pathology</topic><topic>Neoplasms, Second Primary - surgery</topic><topic>Non-small cell lung cancer</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Resection</topic><topic>Second primary lung cancer</topic><topic>Survival</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Meerbeeck, J.</creatorcontrib><creatorcontrib>Weyler, J.</creatorcontrib><creatorcontrib>Thibaut, A.</creatorcontrib><creatorcontrib>Vansteenkiste, J.</creatorcontrib><creatorcontrib>Aumann, J.</creatorcontrib><creatorcontrib>Deneffe, G.</creatorcontrib><creatorcontrib>Galdermans, D.</creatorcontrib><creatorcontrib>Haelterman, M.</creatorcontrib><creatorcontrib>Joos, G.</creatorcontrib><creatorcontrib>Noppen, M.</creatorcontrib><creatorcontrib>Pinson, P.</creatorcontrib><creatorcontrib>Tasson, J.</creatorcontrib><creatorcontrib>Van Den Eeckhout, A.</creatorcontrib><creatorcontrib>Uydebrouck, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Meerbeeck, J.</au><au>Weyler, J.</au><au>Thibaut, A.</au><au>Vansteenkiste, J.</au><au>Aumann, J.</au><au>Deneffe, G.</au><au>Galdermans, D.</au><au>Haelterman, M.</au><au>Joos, G.</au><au>Noppen, M.</au><au>Pinson, P.</au><au>Tasson, J.</au><au>Van Den Eeckhout, A.</au><au>Uydebrouck, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Second primary lung cancer in Flanders: frequency, clinical presentation, treatment and prognosis</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>15</volume><issue>3</issue><spage>281</spage><epage>295</epage><pages>281-295</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><abstract>Patient and tumour characteristics of 23 patients presenting with a second primary lung cancer were analysed and compared with 534 patients with radically resected stage 1 non-small cell lung cancer (NSCLC). None of these characteristics is associated with a higher occurrence rate for second primary lung cancer. Prognosis in the latter patients is significantly worse than after resection of a ‘solitary’ NSCLC: the median survival time (MST) after resection of the first tumour is 50 months; after diagnosis of the second tumour only 14 months. Surgically retreated patients have a prognosis that is similar to that after resection of a ‘solitary’ NSCLC. No separate independent prognostic factors responsible for this surivival difference could be isolated. Squamous histology and central location are associated with a longer recurrence free survival time. We conclude that the occurrence of a second primary lung cancer can not be predicted based on patient or tumour characteristics and that only surgical retreatment offers a chance of long survival in these patients.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>8959675</pmid><doi>10.1016/0169-5002(95)00593-5</doi><tpages>15</tpages></addata></record> |
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| ispartof | Lung cancer (Amsterdam, Netherlands), 1996-11, Vol.15 (3), p.281-295 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Belgium - epidemiology Biopsy Carcinoma, Non-Small-Cell Lung - epidemiology Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Female Follow-Up Studies Humans Incidence Lung Neoplasms - epidemiology Lung Neoplasms - pathology Lung Neoplasms - surgery Male Middle Aged Neoplasm Staging Neoplasms, Second Primary - epidemiology Neoplasms, Second Primary - pathology Neoplasms, Second Primary - surgery Non-small cell lung cancer Prognosis Prospective Studies Recurrence Resection Second primary lung cancer Survival Survival Rate |
| title | Second primary lung cancer in Flanders: frequency, clinical presentation, treatment and prognosis |
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