Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat

Rats were trained to lever press on a differential reinforcement of low rates (DRL-18 s) schedule. They were then allocated to four treatment groups. These were: hippocampal aspiration lesions [HIPP]; implantation of osmotic minipumps for intraventricular infusion of either (a) the NMDA receptor ant...

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Veröffentlicht in:	Experimental brain research 1988-01, Vol.73 (1), p.181-188
Hauptverfasser:	TONKISS, J, MORRIS, R. G. M, RAWLINS, J. N. P
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate Animals Biological and medical sciences Hippocampus - drug effects Hippocampus - physiology Injections, Intraventricular Male Medical sciences Memory - physiology Miscellaneous Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - physiology Reinforcement (Psychology) Retention (Psychology) - drug effects Retention (Psychology) - physiology Valine - analogs & derivatives Valine - pharmacology
Online-Zugang:	Volltext
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