Suppression of t lymphocyte proliferation by peritoneal macrophages in chickens
The mechanism of the suppression of lymphocyte proliferation by peritoneal macrophages (MPs) in chickens and the presence of a suppressive substance in the culture supernatant of MPs were studied. The results showed that gelatin- and pepton-induced peritoneal MPs had an inhibitory accessory function...
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| Veröffentlicht in: | Developmental and comparative immunology 1996-05, Vol.20 (3), p.183-191 |
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| container_end_page | 191 |
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| container_title | Developmental and comparative immunology |
| container_volume | 20 |
| creator | Date, Katsuhiro Okamoto, Takayuki Kurata, Maki Baba, Tsuyoshi Kodama, Hiroshi Mukamoto, Masafumi Tsuji, Sachiyo |
| description | The mechanism of the suppression of lymphocyte proliferation by peritoneal macrophages (MPs) in chickens and the presence of a suppressive substance in the culture supernatant of MPs were studied.
The results showed that gelatin- and pepton-induced peritoneal MPs had an inhibitory accessory function against blastogenesis of mitogen-stimulated splenic lymphocytes and that resident peritoneal MPs had an enhanced accessory function.
The suppressive factor produced by gelatin-induced peritoneal MPs is a protein having a pI of 3.6 and a molecular weight of 64,000 and it is physically and chemically a relatively stable substance. Moreover, it has no cytotoxic effect against lymphocytes and it was verified that the suppressor in the culture supernatant of MPs was not prostaglandin E
2 or α-acid glycoprotein. |
| doi_str_mv | 10.1016/0145-305X(96)00008-0 |
| format | Article |
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The results showed that gelatin- and pepton-induced peritoneal MPs had an inhibitory accessory function against blastogenesis of mitogen-stimulated splenic lymphocytes and that resident peritoneal MPs had an enhanced accessory function.
The suppressive factor produced by gelatin-induced peritoneal MPs is a protein having a pI of 3.6 and a molecular weight of 64,000 and it is physically and chemically a relatively stable substance. Moreover, it has no cytotoxic effect against lymphocytes and it was verified that the suppressor in the culture supernatant of MPs was not prostaglandin E
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The results showed that gelatin- and pepton-induced peritoneal MPs had an inhibitory accessory function against blastogenesis of mitogen-stimulated splenic lymphocytes and that resident peritoneal MPs had an enhanced accessory function.
The suppressive factor produced by gelatin-induced peritoneal MPs is a protein having a pI of 3.6 and a molecular weight of 64,000 and it is physically and chemically a relatively stable substance. Moreover, it has no cytotoxic effect against lymphocytes and it was verified that the suppressor in the culture supernatant of MPs was not prostaglandin E
2 or α-acid glycoprotein.</description><subject>Animals</subject><subject>Cell-Free System - immunology</subject><subject>Cells, Cultured</subject><subject>Chicken</subject><subject>Chickens</subject><subject>Cytotoxicity, Immunologic</subject><subject>Gelatin - pharmacology</subject><subject>Immunosuppressive Agents - chemistry</subject><subject>Immunosuppressive Agents - isolation & purification</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocyte proliferation</subject><subject>Macrophage Activation - drug effects</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Macrophages, Peritoneal - physiology</subject><subject>Peritoneal macrophages</subject><subject>Proteins</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><subject>Suppressor factor</subject><subject>T-Lymphocytes - immunology</subject><issn>0145-305X</issn><issn>1879-0089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6DxR6Ej1UM82mTS6CLH7Bwh5U8BbadOpG-2XSCv33pu6yR80lDO8zk8xDyCnQK6AQX1OY85BR_nYh40vqjwjpHpmCSGToC7lPpjvkkBw59_ELAZ2QiZCcc8mmZPXct61F50xTB00RdEE5VO260UOHQWub0hRo025MsyFo0ZquqTEtgyrVtmnX6Tu6wNSBXhv9ibU7JgdFWjo82d4z8np_97J4DJerh6fF7TLUjCVdWEAhdIowl3lEowjyhEEuKWa5oJLTOImB6TkXEgQmkcz8Dh6XmjNggJiwGTnfzPV__OrRdaoyTmNZpjU2vVOJiIFGTPwLAhc8koJ6cL4B_V7OWSxUa02V2kEBVaNwNdpUo00lfTG6VGPb2XZ-n1WY75q2hn1-s8nR2_g2aJXTBmuNubGoO5U35u8HfgBA3Y-q</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>Date, Katsuhiro</creator><creator>Okamoto, Takayuki</creator><creator>Kurata, Maki</creator><creator>Baba, Tsuyoshi</creator><creator>Kodama, Hiroshi</creator><creator>Mukamoto, Masafumi</creator><creator>Tsuji, Sachiyo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19960501</creationdate><title>Suppression of t lymphocyte proliferation by peritoneal macrophages in chickens</title><author>Date, Katsuhiro ; Okamoto, Takayuki ; Kurata, Maki ; Baba, Tsuyoshi ; Kodama, Hiroshi ; Mukamoto, Masafumi ; Tsuji, Sachiyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-f1f8cae149d20221d731d90ebd8095067613c458918e729b305cae9c53131ee73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Cell-Free System - immunology</topic><topic>Cells, Cultured</topic><topic>Chicken</topic><topic>Chickens</topic><topic>Cytotoxicity, Immunologic</topic><topic>Gelatin - pharmacology</topic><topic>Immunosuppressive Agents - chemistry</topic><topic>Immunosuppressive Agents - isolation & purification</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocyte proliferation</topic><topic>Macrophage Activation - drug effects</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>Macrophages, Peritoneal - physiology</topic><topic>Peritoneal macrophages</topic><topic>Proteins</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><topic>Suppressor factor</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Date, Katsuhiro</creatorcontrib><creatorcontrib>Okamoto, Takayuki</creatorcontrib><creatorcontrib>Kurata, Maki</creatorcontrib><creatorcontrib>Baba, Tsuyoshi</creatorcontrib><creatorcontrib>Kodama, Hiroshi</creatorcontrib><creatorcontrib>Mukamoto, Masafumi</creatorcontrib><creatorcontrib>Tsuji, Sachiyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental and comparative immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Date, Katsuhiro</au><au>Okamoto, Takayuki</au><au>Kurata, Maki</au><au>Baba, Tsuyoshi</au><au>Kodama, Hiroshi</au><au>Mukamoto, Masafumi</au><au>Tsuji, Sachiyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of t lymphocyte proliferation by peritoneal macrophages in chickens</atitle><jtitle>Developmental and comparative immunology</jtitle><addtitle>Dev Comp Immunol</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>20</volume><issue>3</issue><spage>183</spage><epage>191</epage><pages>183-191</pages><issn>0145-305X</issn><eissn>1879-0089</eissn><abstract>The mechanism of the suppression of lymphocyte proliferation by peritoneal macrophages (MPs) in chickens and the presence of a suppressive substance in the culture supernatant of MPs were studied.
The results showed that gelatin- and pepton-induced peritoneal MPs had an inhibitory accessory function against blastogenesis of mitogen-stimulated splenic lymphocytes and that resident peritoneal MPs had an enhanced accessory function.
The suppressive factor produced by gelatin-induced peritoneal MPs is a protein having a pI of 3.6 and a molecular weight of 64,000 and it is physically and chemically a relatively stable substance. Moreover, it has no cytotoxic effect against lymphocytes and it was verified that the suppressor in the culture supernatant of MPs was not prostaglandin E
2 or α-acid glycoprotein.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>8955593</pmid><doi>10.1016/0145-305X(96)00008-0</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Developmental and comparative immunology, 1996-05, Vol.20 (3), p.183-191 |
| issn | 0145-305X 1879-0089 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell-Free System - immunology Cells, Cultured Chicken Chickens Cytotoxicity, Immunologic Gelatin - pharmacology Immunosuppressive Agents - chemistry Immunosuppressive Agents - isolation & purification Immunosuppressive Agents - pharmacology Lymphocyte Activation - drug effects Lymphocyte proliferation Macrophage Activation - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - physiology Peritoneal macrophages Proteins Spleen - cytology Spleen - immunology Suppressor factor T-Lymphocytes - immunology |
| title | Suppression of t lymphocyte proliferation by peritoneal macrophages in chickens |
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