Spatial Working Memory and Strategy Formation in Patients with Frontal Lobe Excisions
Spatial working memory was investigated in 20 patients with unilateral neurosurgical excisions of the frontal cortex (UFL), nine with right (RFL) and eleven with left lesions (LFL), comparing their performance to a matched control group. Spatial memory was tested using the Executive Golf Task, a tes...
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| Veröffentlicht in: | Cortex 1996-12, Vol.32 (4), p.613-630 |
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| creator | Miotto, Eliane C. Bullock, Peter Polkey, Charles E. Morris, Robin G. |
| description | Spatial working memory was investigated in 20 patients with unilateral neurosurgical excisions of the frontal cortex (UFL), nine with right (RFL) and eleven with left lesions (LFL), comparing their performance to a matched control group. Spatial memory was tested using the Executive Golf Task, a test that also measures spatial strategy formation. Overall the UFL were significantly impaired, the greatest impairment being found in the RFL group. The difference between the RFL and LFL groups was abolished when a measure of strategy formation was used as a covariate in the analysis. A further test of spatial working memory, the Owl Spatial Working Memory Task, which prevents the use of a spatial strategy, showed a significant and equivalent impairment in both the RFL and LFL patients. The data are consistent with neuropsychological and functional neuroimaging investigations supporting the role of the pre-frontal cortex in spatial working memory. |
| doi_str_mv | 10.1016/S0010-9452(96)80034-7 |
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Spatial memory was tested using the Executive Golf Task, a test that also measures spatial strategy formation. Overall the UFL were significantly impaired, the greatest impairment being found in the RFL group. The difference between the RFL and LFL groups was abolished when a measure of strategy formation was used as a covariate in the analysis. A further test of spatial working memory, the Owl Spatial Working Memory Task, which prevents the use of a spatial strategy, showed a significant and equivalent impairment in both the RFL and LFL patients. The data are consistent with neuropsychological and functional neuroimaging investigations supporting the role of the pre-frontal cortex in spatial working memory.</description><identifier>ISSN: 0010-9452</identifier><identifier>EISSN: 1973-8102</identifier><identifier>DOI: 10.1016/S0010-9452(96)80034-7</identifier><identifier>PMID: 8954242</identifier><language>eng</language><publisher>Italy: Elsevier Ltd</publisher><subject>Adult ; Aged ; Epilepsy - surgery ; Female ; Frontal Lobe - physiology ; Frontal Lobe - surgery ; Humans ; Male ; Memory - physiology ; Middle Aged ; Prognosis ; Task Performance and Analysis</subject><ispartof>Cortex, 1996-12, Vol.32 (4), p.613-630</ispartof><rights>1996 Mason S.p.A.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-c7baae2af939deefd69e1284a5ec1eb10ebf72fc3f39a16a6bf9bdccb2f8a4483</citedby><cites>FETCH-LOGICAL-c391t-c7baae2af939deefd69e1284a5ec1eb10ebf72fc3f39a16a6bf9bdccb2f8a4483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0010945296800347$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8954242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miotto, Eliane C.</creatorcontrib><creatorcontrib>Bullock, Peter</creatorcontrib><creatorcontrib>Polkey, Charles E.</creatorcontrib><creatorcontrib>Morris, Robin G.</creatorcontrib><title>Spatial Working Memory and Strategy Formation in Patients with Frontal Lobe Excisions</title><title>Cortex</title><addtitle>Cortex</addtitle><description>Spatial working memory was investigated in 20 patients with unilateral neurosurgical excisions of the frontal cortex (UFL), nine with right (RFL) and eleven with left lesions (LFL), comparing their performance to a matched control group. Spatial memory was tested using the Executive Golf Task, a test that also measures spatial strategy formation. Overall the UFL were significantly impaired, the greatest impairment being found in the RFL group. The difference between the RFL and LFL groups was abolished when a measure of strategy formation was used as a covariate in the analysis. A further test of spatial working memory, the Owl Spatial Working Memory Task, which prevents the use of a spatial strategy, showed a significant and equivalent impairment in both the RFL and LFL patients. The data are consistent with neuropsychological and functional neuroimaging investigations supporting the role of the pre-frontal cortex in spatial working memory.</description><subject>Adult</subject><subject>Aged</subject><subject>Epilepsy - surgery</subject><subject>Female</subject><subject>Frontal Lobe - physiology</subject><subject>Frontal Lobe - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Task Performance and Analysis</subject><issn>0010-9452</issn><issn>1973-8102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq2qCELan4DkU9Uetthe73p9qhBKAClVK4WoR8vrHYMhuw62Q8m_x_kQ15xmpPd5Z6QHoQtKflJC68s5IZQUklfsu6x_NISUvBCf0IhKURYNJewzGn0gZ-g8xidCGGmq6hSdNrLijLMRWsxXOjm9xP98eHbDA_4NvQ8brIcOz1PQCR42eOpDnyk_YDfgv3mDIUX836VHPA1-SLk-8y3gyZtxMWPxCzqxehnh62GO0WI6ub--LWZ_bu6ur2aFKSVNhRGt1sC0laXsAGxXS6Cs4boCQ6GlBFormDWlLaWmta5bK9vOmJbZRnPelGP0bX93FfzLGmJSvYsGlks9gF9HJZqaCFEdB2ldCk4pz2C1B03wMQawahVcr8NGUaK23tXOu9pKVbJWO-9K5N7F4cG67aH7aB1E5_zXPoes49VBUNFkjQY6F8Ak1Xl35MM7wDCUDw</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Miotto, Eliane C.</creator><creator>Bullock, Peter</creator><creator>Polkey, Charles E.</creator><creator>Morris, Robin G.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>19961201</creationdate><title>Spatial Working Memory and Strategy Formation in Patients with Frontal Lobe Excisions</title><author>Miotto, Eliane C. ; Bullock, Peter ; Polkey, Charles E. ; Morris, Robin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-c7baae2af939deefd69e1284a5ec1eb10ebf72fc3f39a16a6bf9bdccb2f8a4483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Epilepsy - surgery</topic><topic>Female</topic><topic>Frontal Lobe - physiology</topic><topic>Frontal Lobe - surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Task Performance and Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miotto, Eliane C.</creatorcontrib><creatorcontrib>Bullock, Peter</creatorcontrib><creatorcontrib>Polkey, Charles E.</creatorcontrib><creatorcontrib>Morris, Robin G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Cortex</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miotto, Eliane C.</au><au>Bullock, Peter</au><au>Polkey, Charles E.</au><au>Morris, Robin G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial Working Memory and Strategy Formation in Patients with Frontal Lobe Excisions</atitle><jtitle>Cortex</jtitle><addtitle>Cortex</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>32</volume><issue>4</issue><spage>613</spage><epage>630</epage><pages>613-630</pages><issn>0010-9452</issn><eissn>1973-8102</eissn><abstract>Spatial working memory was investigated in 20 patients with unilateral neurosurgical excisions of the frontal cortex (UFL), nine with right (RFL) and eleven with left lesions (LFL), comparing their performance to a matched control group. 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| ispartof | Cortex, 1996-12, Vol.32 (4), p.613-630 |
| issn | 0010-9452 1973-8102 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged Epilepsy - surgery Female Frontal Lobe - physiology Frontal Lobe - surgery Humans Male Memory - physiology Middle Aged Prognosis Task Performance and Analysis |
| title | Spatial Working Memory and Strategy Formation in Patients with Frontal Lobe Excisions |
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