Effect of a prostacyclin analog OP-2507 on acute ischemic cerebral edema in cats
We evaluated the inhibitory activity of a novel prostacyclin analog, OP-2507 (15-cis-(4-n-propylcyclohexyl)-16,17,18,19,20-pentanor-deoxy-6,9α-nitriloprostaglandin F 1 methyl ester) on the brain edema induced by occlusion of the middle cerebral artery in cats. Middle cerebral artery occlusion for 4...
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| Veröffentlicht in: | European journal of pharmacology 1988-07, Vol.152 (1), p.63-70 |
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| container_title | European journal of pharmacology |
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| creator | Terawaki, Tamiya Takakuwa, Toshio Iguchi, Sadahiko Wakitani, Korekiyo Kira, Heizo Okegawa, Tadao Kawasaki, Akiyoshi Masuda, Yoshinobu |
| description | We evaluated the inhibitory activity of a novel prostacyclin analog, OP-2507 (15-cis-(4-n-propylcyclohexyl)-16,17,18,19,20-pentanor-deoxy-6,9α-nitriloprostaglandin F
1 methyl ester) on the brain edema induced by occlusion of the middle cerebral artery in cats. Middle cerebral artery occlusion for 4 h caused a decrease of regional cerebral blood flow. The specific gravity of the cerebral cortex measured 4 h after the middle cerebral artery occlusion as an index of cerebral edema showed a significant reduction. Intravenous infusion of OP-2507 at infusion rates of 10 and 50 ng/kg per min was started 30 min before the middle cerebral artery occlusion and was continued for 4.5 h. While OP-2507 did not affect the blood pressure, heart rate and regional cerebral blood flow before and after the middle cerebral artery occlusion, the reduction of the specific gravity of cerebral cortex was significantly prevented by OP-2507 treatment at both doses. Prostacyclin prevented the reduction of the specific gravity only at the higher dose of 50 ng/kg per min. The present results indicate the potential usefulness of OP-2507 in acute ischemic cerebral disorders. |
| doi_str_mv | 10.1016/0014-2999(88)90836-9 |
| format | Article |
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1 methyl ester) on the brain edema induced by occlusion of the middle cerebral artery in cats. Middle cerebral artery occlusion for 4 h caused a decrease of regional cerebral blood flow. The specific gravity of the cerebral cortex measured 4 h after the middle cerebral artery occlusion as an index of cerebral edema showed a significant reduction. Intravenous infusion of OP-2507 at infusion rates of 10 and 50 ng/kg per min was started 30 min before the middle cerebral artery occlusion and was continued for 4.5 h. While OP-2507 did not affect the blood pressure, heart rate and regional cerebral blood flow before and after the middle cerebral artery occlusion, the reduction of the specific gravity of cerebral cortex was significantly prevented by OP-2507 treatment at both doses. Prostacyclin prevented the reduction of the specific gravity only at the higher dose of 50 ng/kg per min. The present results indicate the potential usefulness of OP-2507 in acute ischemic cerebral disorders.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(88)90836-9</identifier><identifier>PMID: 3061830</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Brain - pathology ; Brain Edema - drug therapy ; Brain Edema - etiology ; Brain Edema - pathology ; Brain Ischemia - complications ; Cardiovascular system ; Cats ; Cerebral artery occlusion ; Cerebral edema (ischemic) ; Epoprostenol - therapeutic use ; Female ; Heart Rate - drug effects ; Infusions, Intravenous ; Male ; Medical sciences ; OP-2507 ; Pharmacology. Drug treatments ; Prostacyclin analog (stable) ; Specific Gravity ; Specific gravity of cerebral cortex ; Stereotaxic Techniques ; Time Factors ; Vasodilator agents. Cerebral vasodilators</subject><ispartof>European journal of pharmacology, 1988-07, Vol.152 (1), p.63-70</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-5b5a8baf97005a99e39b93eb23f72e82207eaa9dfdf50f687fe54d292e409fbc3</citedby><cites>FETCH-LOGICAL-c483t-5b5a8baf97005a99e39b93eb23f72e82207eaa9dfdf50f687fe54d292e409fbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(88)90836-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7221753$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3061830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terawaki, Tamiya</creatorcontrib><creatorcontrib>Takakuwa, Toshio</creatorcontrib><creatorcontrib>Iguchi, Sadahiko</creatorcontrib><creatorcontrib>Wakitani, Korekiyo</creatorcontrib><creatorcontrib>Kira, Heizo</creatorcontrib><creatorcontrib>Okegawa, Tadao</creatorcontrib><creatorcontrib>Kawasaki, Akiyoshi</creatorcontrib><creatorcontrib>Masuda, Yoshinobu</creatorcontrib><title>Effect of a prostacyclin analog OP-2507 on acute ischemic cerebral edema in cats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>We evaluated the inhibitory activity of a novel prostacyclin analog, OP-2507 (15-cis-(4-n-propylcyclohexyl)-16,17,18,19,20-pentanor-deoxy-6,9α-nitriloprostaglandin F
1 methyl ester) on the brain edema induced by occlusion of the middle cerebral artery in cats. Middle cerebral artery occlusion for 4 h caused a decrease of regional cerebral blood flow. The specific gravity of the cerebral cortex measured 4 h after the middle cerebral artery occlusion as an index of cerebral edema showed a significant reduction. Intravenous infusion of OP-2507 at infusion rates of 10 and 50 ng/kg per min was started 30 min before the middle cerebral artery occlusion and was continued for 4.5 h. While OP-2507 did not affect the blood pressure, heart rate and regional cerebral blood flow before and after the middle cerebral artery occlusion, the reduction of the specific gravity of cerebral cortex was significantly prevented by OP-2507 treatment at both doses. Prostacyclin prevented the reduction of the specific gravity only at the higher dose of 50 ng/kg per min. The present results indicate the potential usefulness of OP-2507 in acute ischemic cerebral disorders.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Brain - pathology</subject><subject>Brain Edema - drug therapy</subject><subject>Brain Edema - etiology</subject><subject>Brain Edema - pathology</subject><subject>Brain Ischemia - complications</subject><subject>Cardiovascular system</subject><subject>Cats</subject><subject>Cerebral artery occlusion</subject><subject>Cerebral edema (ischemic)</subject><subject>Epoprostenol - therapeutic use</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>OP-2507</subject><subject>Pharmacology. Drug treatments</subject><subject>Prostacyclin analog (stable)</subject><subject>Specific Gravity</subject><subject>Specific gravity of cerebral cortex</subject><subject>Stereotaxic Techniques</subject><subject>Time Factors</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9bb6DxSykKKLsSfJZJJsBCmtCoV2UdfhTOZEI_NRk7lC_31zvZe71FUg53kPL89h7I2AjwJEdwEg2kY6595b-8GBVV3jnrGNsMY1YIR8zjZH5CU7LeUXAGgn9Qk7UdAJq2DD7q5ipLDyJXLkD3kpK4bHMKaZ44zj8oPf3jVSg-FL_QnblXgq4SdNKfBAmfqMI6eBJuQ1EnAtr9iLiGOh14f3jH2_vrq__Nrc3H75dvn5pgmtVWuje422x-hM7YTOkXK9U9RLFY0kKyUYQnRDHKKG2FkTSbeDdJJacLEP6oyd7_fW0r-3VFY_1WY0jjjTsi3e2A6MMua_oNCgQXZQwXYPhqqhZIr-IacJ86MX4HfG_U6n3-n01vq_xr2rsbeH_dt-ouEYOiiu83eHOZaAY8w4h1SOmJFSGK0q9mmPUZX2J1H2JSSaAw0p1wP5YUn_7vEEmaua3Q</recordid><startdate>19880726</startdate><enddate>19880726</enddate><creator>Terawaki, Tamiya</creator><creator>Takakuwa, Toshio</creator><creator>Iguchi, Sadahiko</creator><creator>Wakitani, Korekiyo</creator><creator>Kira, Heizo</creator><creator>Okegawa, Tadao</creator><creator>Kawasaki, Akiyoshi</creator><creator>Masuda, Yoshinobu</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880726</creationdate><title>Effect of a prostacyclin analog OP-2507 on acute ischemic cerebral edema in cats</title><author>Terawaki, Tamiya ; Takakuwa, Toshio ; Iguchi, Sadahiko ; Wakitani, Korekiyo ; Kira, Heizo ; Okegawa, Tadao ; Kawasaki, Akiyoshi ; Masuda, Yoshinobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-5b5a8baf97005a99e39b93eb23f72e82207eaa9dfdf50f687fe54d292e409fbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Brain - pathology</topic><topic>Brain Edema - drug therapy</topic><topic>Brain Edema - etiology</topic><topic>Brain Edema - pathology</topic><topic>Brain Ischemia - complications</topic><topic>Cardiovascular system</topic><topic>Cats</topic><topic>Cerebral artery occlusion</topic><topic>Cerebral edema (ischemic)</topic><topic>Epoprostenol - therapeutic use</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>OP-2507</topic><topic>Pharmacology. Drug treatments</topic><topic>Prostacyclin analog (stable)</topic><topic>Specific Gravity</topic><topic>Specific gravity of cerebral cortex</topic><topic>Stereotaxic Techniques</topic><topic>Time Factors</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terawaki, Tamiya</creatorcontrib><creatorcontrib>Takakuwa, Toshio</creatorcontrib><creatorcontrib>Iguchi, Sadahiko</creatorcontrib><creatorcontrib>Wakitani, Korekiyo</creatorcontrib><creatorcontrib>Kira, Heizo</creatorcontrib><creatorcontrib>Okegawa, Tadao</creatorcontrib><creatorcontrib>Kawasaki, Akiyoshi</creatorcontrib><creatorcontrib>Masuda, Yoshinobu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terawaki, Tamiya</au><au>Takakuwa, Toshio</au><au>Iguchi, Sadahiko</au><au>Wakitani, Korekiyo</au><au>Kira, Heizo</au><au>Okegawa, Tadao</au><au>Kawasaki, Akiyoshi</au><au>Masuda, Yoshinobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a prostacyclin analog OP-2507 on acute ischemic cerebral edema in cats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1988-07-26</date><risdate>1988</risdate><volume>152</volume><issue>1</issue><spage>63</spage><epage>70</epage><pages>63-70</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>We evaluated the inhibitory activity of a novel prostacyclin analog, OP-2507 (15-cis-(4-n-propylcyclohexyl)-16,17,18,19,20-pentanor-deoxy-6,9α-nitriloprostaglandin F
1 methyl ester) on the brain edema induced by occlusion of the middle cerebral artery in cats. Middle cerebral artery occlusion for 4 h caused a decrease of regional cerebral blood flow. The specific gravity of the cerebral cortex measured 4 h after the middle cerebral artery occlusion as an index of cerebral edema showed a significant reduction. Intravenous infusion of OP-2507 at infusion rates of 10 and 50 ng/kg per min was started 30 min before the middle cerebral artery occlusion and was continued for 4.5 h. While OP-2507 did not affect the blood pressure, heart rate and regional cerebral blood flow before and after the middle cerebral artery occlusion, the reduction of the specific gravity of cerebral cortex was significantly prevented by OP-2507 treatment at both doses. Prostacyclin prevented the reduction of the specific gravity only at the higher dose of 50 ng/kg per min. The present results indicate the potential usefulness of OP-2507 in acute ischemic cerebral disorders.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>3061830</pmid><doi>10.1016/0014-2999(88)90836-9</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1988-07, Vol.152 (1), p.63-70 |
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| subjects | Animals Biological and medical sciences Blood Pressure - drug effects Brain - pathology Brain Edema - drug therapy Brain Edema - etiology Brain Edema - pathology Brain Ischemia - complications Cardiovascular system Cats Cerebral artery occlusion Cerebral edema (ischemic) Epoprostenol - therapeutic use Female Heart Rate - drug effects Infusions, Intravenous Male Medical sciences OP-2507 Pharmacology. Drug treatments Prostacyclin analog (stable) Specific Gravity Specific gravity of cerebral cortex Stereotaxic Techniques Time Factors Vasodilator agents. Cerebral vasodilators |
| title | Effect of a prostacyclin analog OP-2507 on acute ischemic cerebral edema in cats |
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