The influence of panic attacks on response to phenelzine and amitriptyline in depressed outpatients
A total of 169 depressed outpatients completed a 6-week double-blind study designed to compare the relative efficacy of a tricyclic antidepressant (amitriptyline) with a monoamine oxidase inhibitor (phenelzine). Various "target" symptoms reported to predict preferential response to monoami...
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| Veröffentlicht in: | Journal of clinical psychopharmacology 1988-08, Vol.8 (4), p.246-253 |
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| container_title | Journal of clinical psychopharmacology |
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| creator | KAYSER, A ROBINSON, D. S YINGLING, K HOWARD, D. B CORCELLA, J LAUX, D |
| description | A total of 169 depressed outpatients completed a 6-week double-blind study designed to compare the relative efficacy of a tricyclic antidepressant (amitriptyline) with a monoamine oxidase inhibitor (phenelzine). Various "target" symptoms reported to predict preferential response to monoamine oxidase inhibitors were assessed. The major finding within the whole patient sample, based on results from serial self-report and interviewer-rated scales, was that phenelzine-treated patients showed greater improvements in anxiety symptoms than did patients treated with amitriptyline. Because of the heterogeneity of the sample, patients were classified into homogeneous subgroups of clinical interest. Data analyses of these subgroups detected important drug treatment differences not discernible by analysis of data from the overall sample. Panic attacks and corresponding anxiety symptoms were reported by about one third of the patients, more often by patients with major depression than with minor depression. Patients who reported "spells of terror or panic" responded preferentially to phenelzine on several measures, particularly on items measuring anxiety. Results suggest that phenelzine may be a preferred drug for treating depressed patients with panic attacks. |
| doi_str_mv | 10.1097/00004714-198808000-00003 |
| format | Article |
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Data analyses of these subgroups detected important drug treatment differences not discernible by analysis of data from the overall sample. Panic attacks and corresponding anxiety symptoms were reported by about one third of the patients, more often by patients with major depression than with minor depression. Patients who reported "spells of terror or panic" responded preferentially to phenelzine on several measures, particularly on items measuring anxiety. 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Drug treatments ; Phenelzine - therapeutic use ; Psychiatric Status Rating Scales ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. 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Because of the heterogeneity of the sample, patients were classified into homogeneous subgroups of clinical interest. Data analyses of these subgroups detected important drug treatment differences not discernible by analysis of data from the overall sample. Panic attacks and corresponding anxiety symptoms were reported by about one third of the patients, more often by patients with major depression than with minor depression. Patients who reported "spells of terror or panic" responded preferentially to phenelzine on several measures, particularly on items measuring anxiety. Results suggest that phenelzine may be a preferred drug for treating depressed patients with panic attacks.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Amitriptyline - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clinical Trials as Topic</subject><subject>Depressive Disorder - complications</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - psychology</subject><subject>Double-Blind Method</subject><subject>Fear</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Outpatients</subject><subject>Panic</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenelzine - therapeutic use</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. 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| subjects | Adolescent Adult Aged Amitriptyline - therapeutic use Biological and medical sciences Clinical Trials as Topic Depressive Disorder - complications Depressive Disorder - drug therapy Depressive Disorder - psychology Double-Blind Method Fear Female Humans Male Medical sciences Middle Aged Neuropharmacology Outpatients Panic Pharmacology. Drug treatments Phenelzine - therapeutic use Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Random Allocation Time Factors |
| title | The influence of panic attacks on response to phenelzine and amitriptyline in depressed outpatients |
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