Effects of moderate ethanol sedation on brain regional 2-deoxyglucose uptake in alcohol-sensitive and alcohol-insensitive rat lines
Acute intraperitoneal ethanol administration (2 g/kg) decreased the accumulation of radioactivity after [14C]2-deoxy-D-glucose injection into grossly dissected brain regions of alcohol-sensitive (ANT) and alcohol-insensitive (AT) rat lines. In autoradiography, the balance of radioactivity uptake bet...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1988-07, Vol.30 (3), p.781-786 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Lindroos, F. Korpi, E.R. |
| description | Acute intraperitoneal ethanol administration (2 g/kg) decreased the accumulation of radioactivity after [14C]2-deoxy-D-glucose injection into grossly dissected brain regions of alcohol-sensitive (ANT) and alcohol-insensitive (AT) rat lines. In autoradiography, the balance of radioactivity uptake between different functional systems (as judged from relative optical density ratios) was changed after ethanol: especially in the ANT rats, areas associated with sensory input were damped but motor relay nuclei were relatively active, suggesting a tendency to motor overactivity relative to sensory input. The ANT rats furthermore showed slight relative damping of corticol associative areas and differences in limbic structures compared to the AT rats, which, provided that changes in the balance between brain regions with a decreased overall activity are meaningful, suggests that the higher level of ethanol-induced motor impairment of the ANT rats may be related to defects in their integration of sensory and motor processes. |
| doi_str_mv | 10.1016/0091-3057(88)90099-8 |
| format | Article |
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In autoradiography, the balance of radioactivity uptake between different functional systems (as judged from relative optical density ratios) was changed after ethanol: especially in the ANT rats, areas associated with sensory input were damped but motor relay nuclei were relatively active, suggesting a tendency to motor overactivity relative to sensory input. The ANT rats furthermore showed slight relative damping of corticol associative areas and differences in limbic structures compared to the AT rats, which, provided that changes in the balance between brain regions with a decreased overall activity are meaningful, suggests that the higher level of ethanol-induced motor impairment of the ANT rats may be related to defects in their integration of sensory and motor processes.</description><subject>2-Deoxyglucose</subject><subject>Acute ethanol</subject><subject>Alcohol-sensitivity</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Biological Transport, Active - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Deoxy Sugars - metabolism</subject><subject>Deoxyglucose - metabolism</subject><subject>Ethanol - pharmacology</subject><subject>Hypnotics and Sedatives</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Specificity</subject><subject>Rats</subject><subject>Reference Values</subject><subject>Selected rat lines</subject><subject>Species Specificity</subject><subject>Toxicology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9rFTEUxYNY6rP6DRSyENHFaDKTvxtBStVCwY2uQyZz00bzkmcyU-zaL27G93juWgiEe88v515yEHpByTtKqHhPiKbdQLh8o9Rb3SrdqUdoQ5UcOk6lfIw2R-QJelrrD0II64U8RadDT6lWcoP-XHgPbq44e7zNExQ7A4b5xqYccYXJziEn3M5YbEi4wHWrbcR9N0H-fXcdF5cr4GU325-AG2Gjyzc5dhVSDXO4BWzTdOyG9L_fRuEYEtRn6MTbWOH54T5D3z9dfDv_0l19_Xx5_vGqc4zKufOOWO-lGlnPmZb96KEnzrEmSkEmMUzjKBkTcgSvPFdecOq55tBrwZyWwxl6vffdlfxrgTqbbagOYrQJ8lKNVIIILdSDIOVEKaKHBrI96EqutYA3uxK2ttwZSswaklkTMGsCRinzLySz-r88-C_jFqbjo0MqTX910G11Nvpikwv1iMleScXX6R_2GLRPuw1QTHUBkoMplJapmXK4f4-_fqWvrA</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>Lindroos, F.</creator><creator>Korpi, E.R.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880701</creationdate><title>Effects of moderate ethanol sedation on brain regional 2-deoxyglucose uptake in alcohol-sensitive and alcohol-insensitive rat lines</title><author>Lindroos, F. ; Korpi, E.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-fc0aff78b4254972bfe20cc4417760d63dbb74467bef8f58f651f595e2964c973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>2-Deoxyglucose</topic><topic>Acute ethanol</topic><topic>Alcohol-sensitivity</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Biological Transport, Active - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Deoxy Sugars - metabolism</topic><topic>Deoxyglucose - metabolism</topic><topic>Ethanol - pharmacology</topic><topic>Hypnotics and Sedatives</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Specificity</topic><topic>Rats</topic><topic>Reference Values</topic><topic>Selected rat lines</topic><topic>Species Specificity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindroos, F.</creatorcontrib><creatorcontrib>Korpi, E.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindroos, F.</au><au>Korpi, E.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of moderate ethanol sedation on brain regional 2-deoxyglucose uptake in alcohol-sensitive and alcohol-insensitive rat lines</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>30</volume><issue>3</issue><spage>781</spage><epage>786</epage><pages>781-786</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Acute intraperitoneal ethanol administration (2 g/kg) decreased the accumulation of radioactivity after [14C]2-deoxy-D-glucose injection into grossly dissected brain regions of alcohol-sensitive (ANT) and alcohol-insensitive (AT) rat lines. 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| ispartof | Pharmacology, biochemistry and behavior, 1988-07, Vol.30 (3), p.781-786 |
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| subjects | 2-Deoxyglucose Acute ethanol Alcohol-sensitivity Alcoholism and acute alcohol poisoning Animals Autoradiography Biological and medical sciences Biological Transport, Active - drug effects Blood Glucose - metabolism Brain Brain - drug effects Brain - metabolism Deoxy Sugars - metabolism Deoxyglucose - metabolism Ethanol - pharmacology Hypnotics and Sedatives Male Medical sciences Organ Specificity Rats Reference Values Selected rat lines Species Specificity Toxicology |
| title | Effects of moderate ethanol sedation on brain regional 2-deoxyglucose uptake in alcohol-sensitive and alcohol-insensitive rat lines |
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