Differential enhancement of rapid eye movement sleep signs in the cat: a comparison of microinjection of the cholinergic agonist carbachol and the β-adrenergic antagonist propranolol on pontogeniculo-occipital wave clusters
The cholinergic agonist carbachol and the β-adrenergic antagonist propranolol were microinjected at the same pontine sites and their effects on polygraphic rapid eye movement (REM) sleep, especially pontogeniculo-occipital (PGO) waves, were measured. While both propranolol and carbachol enhanced PGO...
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| Veröffentlicht in: | Brain research 1988-11, Vol.473 (1), p.116-126 |
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| creator | Denlinger, Steven L. Patarca, Roberto Hobson, J. Allan |
| description | The cholinergic agonist carbachol and the β-adrenergic antagonist propranolol were microinjected at the same pontine sites and their effects on polygraphic rapid eye movement (REM) sleep, especially pontogeniculo-occipital (PGO) waves, were measured. While both propranolol and carbachol enhanced PGO wave activity and polygraphic REM sleep, the carbachol-correlated enhancement was more impressive. The increases in REM sleep signs elicited by carbachol were 5-fold over baseline and lasted throughout the 4-h recording period. Propranolol elicited 2.5-fold increases that were significant in the first 2 h only. Yet, the increase in PGO wave activity evoked by propranolol was equal to that of carbachol during non-REM sleep and wakefulness. The results indicate that while propranolol is less potent in activating the distributed neuronal network responsible for REM sleep generation, it selectively facilitates that part of the network responsible for PGO waves. |
| doi_str_mv | 10.1016/0006-8993(88)90322-8 |
| format | Article |
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Allan</creator><creatorcontrib>Denlinger, Steven L. ; Patarca, Roberto ; Hobson, J. Allan</creatorcontrib><description>The cholinergic agonist carbachol and the β-adrenergic antagonist propranolol were microinjected at the same pontine sites and their effects on polygraphic rapid eye movement (REM) sleep, especially pontogeniculo-occipital (PGO) waves, were measured. While both propranolol and carbachol enhanced PGO wave activity and polygraphic REM sleep, the carbachol-correlated enhancement was more impressive. The increases in REM sleep signs elicited by carbachol were 5-fold over baseline and lasted throughout the 4-h recording period. Propranolol elicited 2.5-fold increases that were significant in the first 2 h only. Yet, the increase in PGO wave activity evoked by propranolol was equal to that of carbachol during non-REM sleep and wakefulness. The results indicate that while propranolol is less potent in activating the distributed neuronal network responsible for REM sleep generation, it selectively facilitates that part of the network responsible for PGO waves.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(88)90322-8</identifier><identifier>PMID: 3208113</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adrenergic Fibers - drug effects ; Adrenergic Fibers - physiology ; Aminergic ; Animals ; Biological and medical sciences ; Carbachol ; Carbachol - pharmacology ; Cat ; Cats ; Cholinergic ; Cholinergic Fibers - drug effects ; Cholinergic Fibers - physiology ; Fundamental and applied biological sciences. Psychology ; Male ; Microinjection ; Microinjections ; Occipital Lobe - drug effects ; Occipital Lobe - physiology ; Pons - drug effects ; Pons - physiology ; Pontine reticular formation ; Propranolol ; Propranolol - pharmacology ; Rapid eye movement sleep ; Reciprocal interaction model ; Sleep, REM - drug effects ; Sleep. Vigilance ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1988-11, Vol.473 (1), p.116-126</ispartof><rights>1988 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-9ba0281f855ea3c7f4e191104de277c9655f684dc27d7265b67865d4358c83623</citedby><cites>FETCH-LOGICAL-c417t-9ba0281f855ea3c7f4e191104de277c9655f684dc27d7265b67865d4358c83623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(88)90322-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7162558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3208113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Denlinger, Steven L.</creatorcontrib><creatorcontrib>Patarca, Roberto</creatorcontrib><creatorcontrib>Hobson, J. Allan</creatorcontrib><title>Differential enhancement of rapid eye movement sleep signs in the cat: a comparison of microinjection of the cholinergic agonist carbachol and the β-adrenergic antagonist propranolol on pontogeniculo-occipital wave clusters</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The cholinergic agonist carbachol and the β-adrenergic antagonist propranolol were microinjected at the same pontine sites and their effects on polygraphic rapid eye movement (REM) sleep, especially pontogeniculo-occipital (PGO) waves, were measured. While both propranolol and carbachol enhanced PGO wave activity and polygraphic REM sleep, the carbachol-correlated enhancement was more impressive. The increases in REM sleep signs elicited by carbachol were 5-fold over baseline and lasted throughout the 4-h recording period. Propranolol elicited 2.5-fold increases that were significant in the first 2 h only. Yet, the increase in PGO wave activity evoked by propranolol was equal to that of carbachol during non-REM sleep and wakefulness. The results indicate that while propranolol is less potent in activating the distributed neuronal network responsible for REM sleep generation, it selectively facilitates that part of the network responsible for PGO waves.</description><subject>Adrenergic Fibers - drug effects</subject><subject>Adrenergic Fibers - physiology</subject><subject>Aminergic</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbachol</subject><subject>Carbachol - pharmacology</subject><subject>Cat</subject><subject>Cats</subject><subject>Cholinergic</subject><subject>Cholinergic Fibers - drug effects</subject><subject>Cholinergic Fibers - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Microinjection</subject><subject>Microinjections</subject><subject>Occipital Lobe - drug effects</subject><subject>Occipital Lobe - physiology</subject><subject>Pons - drug effects</subject><subject>Pons - physiology</subject><subject>Pontine reticular formation</subject><subject>Propranolol</subject><subject>Propranolol - pharmacology</subject><subject>Rapid eye movement sleep</subject><subject>Reciprocal interaction model</subject><subject>Sleep, REM - drug effects</subject><subject>Sleep. Vigilance</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuO1DAQhiMEGpqBG4DkBUKwCPgRJw4LJDQ8pZHYwNpyO5XuGiV2sJ1Gcy0Owhk4Ck6n6SWsrHJ99btcfxXFY0ZfMsrqV5TSulRtK54r9aKlgvNS3Sk2TDW8rHlF7xabM3K_eBDjTQ6FaOlFcSE4VYyJTfH7HfY9BHAJzUDA7Y2zMOaQ-J4EM2FH4BbI6A_rbRwAJhJx5yJBR9IeiDXpNTHE-nEyAaN3S-mINnh0N2ATrjdHdO8HdBB2aInZeYcx5fKwNUuCGNcdqV8_S9Pllk6cS3_RKfgpGOeHDGfRybvkd-DQzoMvvbU4Ycq_-GEO-alhjglCfFjc680Q4dHpvCy-fXj_9epTef3l4-ert9elrViTynZrKFesV1KCEbbpK2AtY7TqgDeNbWsp-1pVneVN1_BabutG1bKrhFRWiZqLy-LZqpub_D5DTHrEaGEYjAM_R51xKplQ_wWZpEo0VGawWsE8yRgD9HoKOJpwqxnVywboxV692KuV0scN0Iv-k5P-vB2hOxedLM_5p6e8idYMfR6oxXjGGlZzKReZNysGeWgHhKCjRcjL0WHIpurO47_7-ANN99LD</recordid><startdate>19881108</startdate><enddate>19881108</enddate><creator>Denlinger, Steven L.</creator><creator>Patarca, Roberto</creator><creator>Hobson, J. Allan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19881108</creationdate><title>Differential enhancement of rapid eye movement sleep signs in the cat: a comparison of microinjection of the cholinergic agonist carbachol and the β-adrenergic antagonist propranolol on pontogeniculo-occipital wave clusters</title><author>Denlinger, Steven L. ; Patarca, Roberto ; Hobson, J. Allan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-9ba0281f855ea3c7f4e191104de277c9655f684dc27d7265b67865d4358c83623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adrenergic Fibers - drug effects</topic><topic>Adrenergic Fibers - physiology</topic><topic>Aminergic</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbachol</topic><topic>Carbachol - pharmacology</topic><topic>Cat</topic><topic>Cats</topic><topic>Cholinergic</topic><topic>Cholinergic Fibers - drug effects</topic><topic>Cholinergic Fibers - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Microinjection</topic><topic>Microinjections</topic><topic>Occipital Lobe - drug effects</topic><topic>Occipital Lobe - physiology</topic><topic>Pons - drug effects</topic><topic>Pons - physiology</topic><topic>Pontine reticular formation</topic><topic>Propranolol</topic><topic>Propranolol - pharmacology</topic><topic>Rapid eye movement sleep</topic><topic>Reciprocal interaction model</topic><topic>Sleep, REM - drug effects</topic><topic>Sleep. Vigilance</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Denlinger, Steven L.</creatorcontrib><creatorcontrib>Patarca, Roberto</creatorcontrib><creatorcontrib>Hobson, J. Allan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Denlinger, Steven L.</au><au>Patarca, Roberto</au><au>Hobson, J. Allan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential enhancement of rapid eye movement sleep signs in the cat: a comparison of microinjection of the cholinergic agonist carbachol and the β-adrenergic antagonist propranolol on pontogeniculo-occipital wave clusters</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1988-11-08</date><risdate>1988</risdate><volume>473</volume><issue>1</issue><spage>116</spage><epage>126</epage><pages>116-126</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The cholinergic agonist carbachol and the β-adrenergic antagonist propranolol were microinjected at the same pontine sites and their effects on polygraphic rapid eye movement (REM) sleep, especially pontogeniculo-occipital (PGO) waves, were measured. While both propranolol and carbachol enhanced PGO wave activity and polygraphic REM sleep, the carbachol-correlated enhancement was more impressive. The increases in REM sleep signs elicited by carbachol were 5-fold over baseline and lasted throughout the 4-h recording period. Propranolol elicited 2.5-fold increases that were significant in the first 2 h only. Yet, the increase in PGO wave activity evoked by propranolol was equal to that of carbachol during non-REM sleep and wakefulness. The results indicate that while propranolol is less potent in activating the distributed neuronal network responsible for REM sleep generation, it selectively facilitates that part of the network responsible for PGO waves.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3208113</pmid><doi>10.1016/0006-8993(88)90322-8</doi><tpages>11</tpages></addata></record> |
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| subjects | Adrenergic Fibers - drug effects Adrenergic Fibers - physiology Aminergic Animals Biological and medical sciences Carbachol Carbachol - pharmacology Cat Cats Cholinergic Cholinergic Fibers - drug effects Cholinergic Fibers - physiology Fundamental and applied biological sciences. Psychology Male Microinjection Microinjections Occipital Lobe - drug effects Occipital Lobe - physiology Pons - drug effects Pons - physiology Pontine reticular formation Propranolol Propranolol - pharmacology Rapid eye movement sleep Reciprocal interaction model Sleep, REM - drug effects Sleep. Vigilance Vertebrates: nervous system and sense organs |
| title | Differential enhancement of rapid eye movement sleep signs in the cat: a comparison of microinjection of the cholinergic agonist carbachol and the β-adrenergic antagonist propranolol on pontogeniculo-occipital wave clusters |
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