Clonidine: placental transfer and neonatal adaption

Clonidine: placental transfer and neonatal adaption

The placental transfer of clonidine was investigated in five pregnancies. Clonidine readily crosses the placenta. The drug elimination in neonates was slow, but the only clinical abnormality was that of a raised arterial blood pressure. Hypertension for at least 24 h was observed in four cases. It i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Early human development 1988-08, Vol.17 (1), p.275-286
Hauptverfasser: Boutroy, M.J., Gisonna, C.R., Legagneur, M.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
Cardiovascular system
clonidine
Clonidine - blood
Clonidine - pharmacokinetics
Clonidine - therapeutic use
Female
Humans
hypertensive pregnancy
Infant, Newborn - blood
Maternal-Fetal Exchange
Medical sciences
neonatal adaption
Pharmacology. Drug treatments
placental transfer
Pre-Eclampsia - drug therapy
Pregnancy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The placental transfer of clonidine was investigated in five pregnancies. Clonidine readily crosses the placenta. The drug elimination in neonates was slow, but the only clinical abnormality was that of a raised arterial blood pressure. Hypertension for at least 24 h was observed in four cases. It is suggested that this may be related to a withdrawal syndrome due to the sudden cessation of the placentally transferred drug.
ISSN:0378-3782
1872-6232
DOI:10.1016/0378-3782(88)90015-1