In situ activation of human erythrocyte prolidase: potential for enzyme replacement therapy in prolidase deficiency

Deficiency of prolidase is frequently associated with skin lesions and mental retardation. Biochemically, the condition is marked by iminodipeptiduria. We have investigated the feasibility of using donor erythrocytes to replace the deficient enzyme. Prolidase occurs in erythrocytes in an inactive fo...

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Veröffentlicht in:	Pediatric research 1988-12, Vol.24 (6), p.709-712
Hauptverfasser:	HECHTMAN, P, RICHTER, A, CORMAN, N, YI-MUN LEONG
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Dipeptidases - deficiency Dipeptidases - metabolism Enzyme Activation Enzymes and enzyme inhibitors Erythrocyte Transfusion Erythrocytes - enzymology Fundamental and applied biological sciences. Psychology Humans Manganese - pharmacology
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