Optimized synthesis of polyglutaraldehyde nanoparticles using central composite design
A central composite design was applied to the optimization of the synthesis of polyglutaraldehyde nanoparticles (PGNP). The effects of monomer concentration, surfactant concentration, pH, oxygen level, and stirring rate on the particle size, polydispersity, surface carboxyl group concentration, and...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1988-08, Vol.77 (8), p.704-710 |
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| container_end_page | 710 |
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| container_issue | 8 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 77 |
| creator | McLeod, A.D. Lam, F.C. Gupta, P.K. Hung, C.T. |
| description | A central composite design was applied to the optimization of the synthesis of polyglutaraldehyde nanoparticles (PGNP). The effects of monomer concentration, surfactant concentration, pH, oxygen level, and stirring rate on the particle size, polydispersity, surface carboxyl group concentration, and yield of PGNP were investigated. The optimal conditions for the synthesis of PGNP were found to be: 7% (w/v) glutaraldehyde, 2.5% (w/v) dextran, pH 12, 70% (v/v) oxygen, and a stirring rate of 1080rpm. Under these conditions, the values of the dependent variables adequately resembled those predicted by the model. The usefulness of these particles in the targeted delivery of cytotoxic drugs is discussed. |
| doi_str_mv | 10.1002/jps.2600770813 |
| format | Article |
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The effects of monomer concentration, surfactant concentration, pH, oxygen level, and stirring rate on the particle size, polydispersity, surface carboxyl group concentration, and yield of PGNP were investigated. The optimal conditions for the synthesis of PGNP were found to be: 7% (w/v) glutaraldehyde, 2.5% (w/v) dextran, pH 12, 70% (v/v) oxygen, and a stirring rate of 1080rpm. Under these conditions, the values of the dependent variables adequately resembled those predicted by the model. The usefulness of these particles in the targeted delivery of cytotoxic drugs is discussed.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600770813</identifier><identifier>PMID: 3145338</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Aldehydes - chemical synthesis ; Biological and medical sciences ; Chemical Phenomena ; Chemistry ; General pharmacology ; Glutaral - analogs & derivatives ; Glutaral - chemical synthesis ; Indicators and Reagents ; Medical sciences ; Microspheres ; Oxidation-Reduction ; Oxygen ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Surface-Active Agents</subject><ispartof>Journal of pharmaceutical sciences, 1988-08, Vol.77 (8), p.704-710</ispartof><rights>1988 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1988 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4563-e5b62b74e503068f3390b7d39c5e4b0533a75892c4ff71d0d5897d7b43536faa3</citedby><cites>FETCH-LOGICAL-c4563-e5b62b74e503068f3390b7d39c5e4b0533a75892c4ff71d0d5897d7b43536faa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600770813$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600770813$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6976015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3145338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McLeod, A.D.</creatorcontrib><creatorcontrib>Lam, F.C.</creatorcontrib><creatorcontrib>Gupta, P.K.</creatorcontrib><creatorcontrib>Hung, C.T.</creatorcontrib><title>Optimized synthesis of polyglutaraldehyde nanoparticles using central composite design</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A central composite design was applied to the optimization of the synthesis of polyglutaraldehyde nanoparticles (PGNP). The effects of monomer concentration, surfactant concentration, pH, oxygen level, and stirring rate on the particle size, polydispersity, surface carboxyl group concentration, and yield of PGNP were investigated. The optimal conditions for the synthesis of PGNP were found to be: 7% (w/v) glutaraldehyde, 2.5% (w/v) dextran, pH 12, 70% (v/v) oxygen, and a stirring rate of 1080rpm. Under these conditions, the values of the dependent variables adequately resembled those predicted by the model. The usefulness of these particles in the targeted delivery of cytotoxic drugs is discussed.</description><subject>Aldehydes - chemical synthesis</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>General pharmacology</subject><subject>Glutaral - analogs & derivatives</subject><subject>Glutaral - chemical synthesis</subject><subject>Indicators and Reagents</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>Oxidation-Reduction</subject><subject>Oxygen</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Surface-Active Agents</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EKtvClRtSDohblkkc28kRFiigilbi62g59mTrki88CSX89RhltYgD4mSN5veeZ94w9iiDbQaQP7sZaZtLAKWgzPgdtslEDqmETN1lmwjkKRdFdZ-dEt0AgAQhTtgJzwrBeblhny_HyXf-J7qEln66RvKUDE0yDu2yb-fJBNM6vF4cJr3ph9GEydsWKZnJ9_vEYj9FIrFDNw7kJ0xcdNj3D9i9xrSEDw_vGfv0-tXH3Zv04vL87e75RWoLIXmKopZ5rQoUwEGWDecV1MrxygosaogjGiXKKrdF06jMgYuFcqouuOCyMYafsaer7xiGbzPSpDtPFtvW9DjMpFUpqopnKoLbFbRhIArY6DH4zoRFZ6B_B6ljkPpPkFHw-OA81x26I35ILvafHPqGrGmbYHrr6YjJSsUbiIhVK3brW1z-86l-d_XhrxHSVetpwh9HrQlftVRcCf3l_bneyZdQ5vxKv4h8ufIYE__uMWiyHnuLzge0k3aD_9e2vwDQHK6W</recordid><startdate>198808</startdate><enddate>198808</enddate><creator>McLeod, A.D.</creator><creator>Lam, F.C.</creator><creator>Gupta, P.K.</creator><creator>Hung, C.T.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198808</creationdate><title>Optimized synthesis of polyglutaraldehyde nanoparticles using central composite design</title><author>McLeod, A.D. ; Lam, F.C. ; Gupta, P.K. ; Hung, C.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4563-e5b62b74e503068f3390b7d39c5e4b0533a75892c4ff71d0d5897d7b43536faa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Aldehydes - chemical synthesis</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>General pharmacology</topic><topic>Glutaral - analogs & derivatives</topic><topic>Glutaral - chemical synthesis</topic><topic>Indicators and Reagents</topic><topic>Medical sciences</topic><topic>Microspheres</topic><topic>Oxidation-Reduction</topic><topic>Oxygen</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Surface-Active Agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McLeod, A.D.</creatorcontrib><creatorcontrib>Lam, F.C.</creatorcontrib><creatorcontrib>Gupta, P.K.</creatorcontrib><creatorcontrib>Hung, C.T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McLeod, A.D.</au><au>Lam, F.C.</au><au>Gupta, P.K.</au><au>Hung, C.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimized synthesis of polyglutaraldehyde nanoparticles using central composite design</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1988-08</date><risdate>1988</risdate><volume>77</volume><issue>8</issue><spage>704</spage><epage>710</epage><pages>704-710</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>A central composite design was applied to the optimization of the synthesis of polyglutaraldehyde nanoparticles (PGNP). The effects of monomer concentration, surfactant concentration, pH, oxygen level, and stirring rate on the particle size, polydispersity, surface carboxyl group concentration, and yield of PGNP were investigated. The optimal conditions for the synthesis of PGNP were found to be: 7% (w/v) glutaraldehyde, 2.5% (w/v) dextran, pH 12, 70% (v/v) oxygen, and a stirring rate of 1080rpm. Under these conditions, the values of the dependent variables adequately resembled those predicted by the model. The usefulness of these particles in the targeted delivery of cytotoxic drugs is discussed.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>3145338</pmid><doi>10.1002/jps.2600770813</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1988-08, Vol.77 (8), p.704-710 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Aldehydes - chemical synthesis Biological and medical sciences Chemical Phenomena Chemistry General pharmacology Glutaral - analogs & derivatives Glutaral - chemical synthesis Indicators and Reagents Medical sciences Microspheres Oxidation-Reduction Oxygen Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Surface-Active Agents |
| title | Optimized synthesis of polyglutaraldehyde nanoparticles using central composite design |
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