Generation of stable test atmospheres of cocaine base and its pyrolyzate, methylecgonidine, and demonstration of their biological activity

Generating controlled test atmospheres of known chemical identity and airborne concentration upon demand is a significant technical obstacle that limits the scope and repeatability of studies of inhaled substances. We addressed this problem as applied to the generation of atmospheres that result fro...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1996-10, Vol.55 (2), p.237-248
Hauptverfasser:	Wood, Ronald W., Graefe, John F., Fang, Ching Ping, Shojaie, Jalil, Chen, Lung Chi, Willetts, Joyce
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosol Aerosols Anhydroecgonine methyl ester Animals Atmosphere Exposure Chambers Biological and medical sciences Body temperature Bradycardia Bronchoconstriction Cardiovascular Cocaine Cocaine - administration & dosage Cocaine - analogs & derivatives Cocaine - pharmacology Condensation aerosols Crack Crack Cocaine - administration & dosage Crack Cocaine - pharmacology Drug addictions Heart rate Hemodynamics - drug effects Male Medical sciences Methylecgonidine Narcotics - administration & dosage Narcotics - pharmacology Particle Size Saimiri Squirrel monkeys Syringes Toxicology
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