The Hairpin Structure of a Topoisomerase II Site DNA Strand Analyzed by Combined NMR and Energy Minimization Methods

We report on the structural study of the single-stranded 19mer oligonucleotide d(AGCTTATC-ATC-GATAAGCT) 22(+). This corre sponds to the 15-to-33(+) strand of pBR322 DNA belonging to a strong cleavage site (site 22) for topoisomerase II coupled to antitumor drugs VP-16 or ellipticine. The partially s...

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Veröffentlicht in:	Journal of molecular biology 1996-11, Vol.263 (5), p.776-788
Hauptverfasser:	Amir-Aslani, Arsia, Mauffret, Olivier, Sourgen, Frédéric, Neplaz, Stéphanie, Maroun, Richard G., Lescot, Elie, Tevanian, Georges, Fermandjian, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrate Conformation Carbohydrates - chemistry DNA - chemistry DNA - metabolism DNA hairpin DNA Topoisomerases, Type II - metabolism energy minimizations Esters loop Magnetic Resonance Spectroscopy NMR Nucleic Acid Conformation Substrate Specificity topoisomerase II
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