Spatial learning deficits in old rats: A model for memory decline in the aged
Spatial learning tasks are sensitive to functional decline in aged laboratory rodents. This is a review of recent work that has examined both the nature of age-related impairments on spatial tasks, and the relation of such deficits to underlying neurobiological mechanisms. The review supports the no...
Gespeichert in:
| Veröffentlicht in: | Neurobiology of aging 1988, Vol.9 (5-6), p.549-556 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 556 |
|---|---|
| container_issue | 5-6 |
| container_start_page | 549 |
| container_title | Neurobiology of aging |
| container_volume | 9 |
| creator | Gallagher, Michela Pelleymounter, Mary Ann |
| description | Spatial learning tasks are sensitive to functional decline in aged laboratory rodents. This is a review of recent work that has examined both the nature of age-related impairments on spatial tasks, and the relation of such deficits to underlying neurobiological mechanisms. The review supports the notion that hippocampal dysfunction underlies the mild/moderate cognitive decline that often accompanies normal aging. Thus the spatial learning deficit in aged rodents is a promising model for understanding the effect of age on brain systems that serve a memory function in humans. |
| doi_str_mv | 10.1016/S0197-4580(88)80112-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78598282</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S019745808880112X</els_id><sourcerecordid>78598282</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-f7ef0002d812506add16658649ede37e2f35acac3450463b2b91b188b3db8283</originalsourceid><addsrcrecordid>eNqFkLtOAzEQRS0ECiHwCZFcISgWbK_t9dIghHhJQRRJkc7y2rPBaB_B3iDl79k8lDbVFPfcmdFBaEzJHSVU3k8JzbOEC0VulLpVhFKWzE_QkAqhEsrz7BQND8g5uojxhxCS8UwO0CAlknEphuhzujSdNxWuwITGNwvsoPTWdxH7BreVw8F08QE_4bp1UOGyDbiGug3rHrSVb2DDdd-AzQLcJTorTRXhaj9HaPb6Mnt-TyZfbx_PT5PEcp52SZlB2f_CnKJMEGmco1IKJXkODtIMWJkKY41NuSBcpgUrclpQpYrUFYqpdISud2uXof1dQex07aOFqjINtKuoMyXynmNHQSokV4qRHhQ70IY2xgClXgZfm7DWlOiNbr3VrTcutVJ6q1vP-954f2BV1OAOrb3fPn_c5dDb-PMQdLQeGgvOB7Cddq0_cuEffbWOCQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15648820</pqid></control><display><type>article</type><title>Spatial learning deficits in old rats: A model for memory decline in the aged</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Gallagher, Michela ; Pelleymounter, Mary Ann</creator><creatorcontrib>Gallagher, Michela ; Pelleymounter, Mary Ann</creatorcontrib><description>Spatial learning tasks are sensitive to functional decline in aged laboratory rodents. This is a review of recent work that has examined both the nature of age-related impairments on spatial tasks, and the relation of such deficits to underlying neurobiological mechanisms. The review supports the notion that hippocampal dysfunction underlies the mild/moderate cognitive decline that often accompanies normal aging. Thus the spatial learning deficit in aged rodents is a promising model for understanding the effect of age on brain systems that serve a memory function in humans.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/S0197-4580(88)80112-X</identifier><identifier>PMID: 3062465</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging ; Aging - metabolism ; Aging - physiology ; Animal models ; Animals ; High-affinity choline uptake ; Hippocampus ; Learning Disorders - physiopathology ; Memory Disorders - physiopathology ; Rats ; Spatial Behavior - physiology ; Spatial learning</subject><ispartof>Neurobiology of aging, 1988, Vol.9 (5-6), p.549-556</ispartof><rights>1988 Pergamon Journals Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-f7ef0002d812506add16658649ede37e2f35acac3450463b2b91b188b3db8283</citedby><cites>FETCH-LOGICAL-c443t-f7ef0002d812506add16658649ede37e2f35acac3450463b2b91b188b3db8283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0197-4580(88)80112-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,4026,27930,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3062465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallagher, Michela</creatorcontrib><creatorcontrib>Pelleymounter, Mary Ann</creatorcontrib><title>Spatial learning deficits in old rats: A model for memory decline in the aged</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Spatial learning tasks are sensitive to functional decline in aged laboratory rodents. This is a review of recent work that has examined both the nature of age-related impairments on spatial tasks, and the relation of such deficits to underlying neurobiological mechanisms. The review supports the notion that hippocampal dysfunction underlies the mild/moderate cognitive decline that often accompanies normal aging. Thus the spatial learning deficit in aged rodents is a promising model for understanding the effect of age on brain systems that serve a memory function in humans.</description><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Aging - physiology</subject><subject>Animal models</subject><subject>Animals</subject><subject>High-affinity choline uptake</subject><subject>Hippocampus</subject><subject>Learning Disorders - physiopathology</subject><subject>Memory Disorders - physiopathology</subject><subject>Rats</subject><subject>Spatial Behavior - physiology</subject><subject>Spatial learning</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOAzEQRS0ECiHwCZFcISgWbK_t9dIghHhJQRRJkc7y2rPBaB_B3iDl79k8lDbVFPfcmdFBaEzJHSVU3k8JzbOEC0VulLpVhFKWzE_QkAqhEsrz7BQND8g5uojxhxCS8UwO0CAlknEphuhzujSdNxWuwITGNwvsoPTWdxH7BreVw8F08QE_4bp1UOGyDbiGug3rHrSVb2DDdd-AzQLcJTorTRXhaj9HaPb6Mnt-TyZfbx_PT5PEcp52SZlB2f_CnKJMEGmco1IKJXkODtIMWJkKY41NuSBcpgUrclpQpYrUFYqpdISud2uXof1dQex07aOFqjINtKuoMyXynmNHQSokV4qRHhQ70IY2xgClXgZfm7DWlOiNbr3VrTcutVJ6q1vP-954f2BV1OAOrb3fPn_c5dDb-PMQdLQeGgvOB7Cddq0_cuEffbWOCQ</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Gallagher, Michela</creator><creator>Pelleymounter, Mary Ann</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Spatial learning deficits in old rats: A model for memory decline in the aged</title><author>Gallagher, Michela ; Pelleymounter, Mary Ann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-f7ef0002d812506add16658649ede37e2f35acac3450463b2b91b188b3db8283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Aging - physiology</topic><topic>Animal models</topic><topic>Animals</topic><topic>High-affinity choline uptake</topic><topic>Hippocampus</topic><topic>Learning Disorders - physiopathology</topic><topic>Memory Disorders - physiopathology</topic><topic>Rats</topic><topic>Spatial Behavior - physiology</topic><topic>Spatial learning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallagher, Michela</creatorcontrib><creatorcontrib>Pelleymounter, Mary Ann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallagher, Michela</au><au>Pelleymounter, Mary Ann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial learning deficits in old rats: A model for memory decline in the aged</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1988</date><risdate>1988</risdate><volume>9</volume><issue>5-6</issue><spage>549</spage><epage>556</epage><pages>549-556</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Spatial learning tasks are sensitive to functional decline in aged laboratory rodents. This is a review of recent work that has examined both the nature of age-related impairments on spatial tasks, and the relation of such deficits to underlying neurobiological mechanisms. The review supports the notion that hippocampal dysfunction underlies the mild/moderate cognitive decline that often accompanies normal aging. Thus the spatial learning deficit in aged rodents is a promising model for understanding the effect of age on brain systems that serve a memory function in humans.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3062465</pmid><doi>10.1016/S0197-4580(88)80112-X</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 1988, Vol.9 (5-6), p.549-556 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78598282 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aging Aging - metabolism Aging - physiology Animal models Animals High-affinity choline uptake Hippocampus Learning Disorders - physiopathology Memory Disorders - physiopathology Rats Spatial Behavior - physiology Spatial learning |
| title | Spatial learning deficits in old rats: A model for memory decline in the aged |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T08%3A49%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spatial%20learning%20deficits%20in%20old%20rats:%20A%20model%20for%20memory%20decline%20in%20the%20aged&rft.jtitle=Neurobiology%20of%20aging&rft.au=Gallagher,%20Michela&rft.date=1988&rft.volume=9&rft.issue=5-6&rft.spage=549&rft.epage=556&rft.pages=549-556&rft.issn=0197-4580&rft.eissn=1558-1497&rft_id=info:doi/10.1016/S0197-4580(88)80112-X&rft_dat=%3Cproquest_cross%3E78598282%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15648820&rft_id=info:pmid/3062465&rft_els_id=S019745808880112X&rfr_iscdi=true |