Double-blind comparison of a dithranol and steroid mixture with a conventional dithranol regimen for chronic psoriasis
SUMMARY Twenty four of 30 patients with chronic plaque psoriasis completed a double‐blind randomized paired comparison of dithranol in Lassar's paste versus dithranol and fluocinonide in Lassar's paste. There was a more rapid reduction in severity of the psoriasis on the side treated with...
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| Veröffentlicht in: | British journal of dermatology (1951) 1988-11, Vol.119 (5), p.623-626 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 119 |
| creator | GRATTAN, C.E.H. CHRISTOPHER, A.P. ROBINSON, M. COWAN, M.A. |
| description | SUMMARY
Twenty four of 30 patients with chronic plaque psoriasis completed a double‐blind randomized paired comparison of dithranol in Lassar's paste versus dithranol and fluocinonide in Lassar's paste. There was a more rapid reduction in severity of the psoriasis on the side treated with the dithranol and fluocinonide mixture, but no difference in the final time to clearance between the two sides. There were fewer burning episodes on the side treated with dithranol and fluocinonide and greater staining of the skin. Of the 20 patients who were subsequently followed up for up to 3 months, 11 had relapsed more on the side treated with dithranol and fluocinonide, two on the side treated with dithranol alone and in seven there was no appreciable difference. It was concluded that the addition of a topical steroid to a conventional dithranol regimen produced more rapid initial clearance and less burning, but more rapid relapse of the psoriasis. |
| doi_str_mv | 10.1111/j.1365-2133.1988.tb03473.x |
| format | Article |
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Twenty four of 30 patients with chronic plaque psoriasis completed a double‐blind randomized paired comparison of dithranol in Lassar's paste versus dithranol and fluocinonide in Lassar's paste. There was a more rapid reduction in severity of the psoriasis on the side treated with the dithranol and fluocinonide mixture, but no difference in the final time to clearance between the two sides. There were fewer burning episodes on the side treated with dithranol and fluocinonide and greater staining of the skin. Of the 20 patients who were subsequently followed up for up to 3 months, 11 had relapsed more on the side treated with dithranol and fluocinonide, two on the side treated with dithranol alone and in seven there was no appreciable difference. It was concluded that the addition of a topical steroid to a conventional dithranol regimen produced more rapid initial clearance and less burning, but more rapid relapse of the psoriasis.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.1988.tb03473.x</identifier><identifier>PMID: 3061441</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Anthralin - therapeutic use ; Biological and medical sciences ; Clinical Trials as Topic ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Fluocinolone Acetonide - analogs & derivatives ; Fluocinonide - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Psoriasis - drug therapy ; Random Allocation ; Recurrence ; Skin, nail, hair, dermoskeleton</subject><ispartof>British journal of dermatology (1951), 1988-11, Vol.119 (5), p.623-626</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4363-fddb15a02c29a966e939a66848ff9e9dff9776a3a376418fec7472dbfdc4bb693</citedby><cites>FETCH-LOGICAL-c4363-fddb15a02c29a966e939a66848ff9e9dff9776a3a376418fec7472dbfdc4bb693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.1988.tb03473.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.1988.tb03473.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6576101$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3061441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GRATTAN, C.E.H.</creatorcontrib><creatorcontrib>CHRISTOPHER, A.P.</creatorcontrib><creatorcontrib>ROBINSON, M.</creatorcontrib><creatorcontrib>COWAN, M.A.</creatorcontrib><title>Double-blind comparison of a dithranol and steroid mixture with a conventional dithranol regimen for chronic psoriasis</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>SUMMARY
Twenty four of 30 patients with chronic plaque psoriasis completed a double‐blind randomized paired comparison of dithranol in Lassar's paste versus dithranol and fluocinonide in Lassar's paste. There was a more rapid reduction in severity of the psoriasis on the side treated with the dithranol and fluocinonide mixture, but no difference in the final time to clearance between the two sides. There were fewer burning episodes on the side treated with dithranol and fluocinonide and greater staining of the skin. Of the 20 patients who were subsequently followed up for up to 3 months, 11 had relapsed more on the side treated with dithranol and fluocinonide, two on the side treated with dithranol alone and in seven there was no appreciable difference. It was concluded that the addition of a topical steroid to a conventional dithranol regimen produced more rapid initial clearance and less burning, but more rapid relapse of the psoriasis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anthralin - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Fluocinolone Acetonide - analogs & derivatives</subject><subject>Fluocinonide - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Psoriasis - drug therapy</subject><subject>Random Allocation</subject><subject>Recurrence</subject><subject>Skin, nail, hair, dermoskeleton</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkctu1DAUhi0EKtPCIyBZCHWXYMeJHbNAohcGqop2AerScnyhHhJ7sJN2-vZ1NNGILV4cL_6Lre8A8B6jEufzcVNiQpuiwoSUmLdtOXaI1IyUuxdgdZBeghVCiBWIU_IaHKe0QQgT1KAjcEQQxXWNV-DhIkxdb4qud15DFYatjC4FD4OFEmo33kfpQw9lVtNoYnAaDm43TtHAx6xmkwr-wfjRBS_7fxLR_HaD8dCGCNV9DN4puE0hOplcegNeWdkn83a5T8Cvr5c_z78V1zfr7-dfrgtVE0oKq3WHG4kqVXHJKTWccElpW7fWcsN1noxRSSRhtMatNYrVrNKd1aruOsrJCTjd925j-DuZNIrBJWX6XnoTpiRY2_CcRNn4aW9UMaQUjRXb6AYZnwRGYoYuNmImK2ayYoYuFuhil8PvllembjD6EF0oZ_3DosukZG8zIOXSwUYbRjGabZ_3tkfXm6f_-IA4u7qgFckFxb7A5VXtDgUy_hGUEdaIux9rgZuKr2_vzsQVeQaJgbAl</recordid><startdate>198811</startdate><enddate>198811</enddate><creator>GRATTAN, C.E.H.</creator><creator>CHRISTOPHER, A.P.</creator><creator>ROBINSON, M.</creator><creator>COWAN, M.A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198811</creationdate><title>Double-blind comparison of a dithranol and steroid mixture with a conventional dithranol regimen for chronic psoriasis</title><author>GRATTAN, C.E.H. ; CHRISTOPHER, A.P. ; ROBINSON, M. ; COWAN, M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4363-fddb15a02c29a966e939a66848ff9e9dff9776a3a376418fec7472dbfdc4bb693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anthralin - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Fluocinolone Acetonide - analogs & derivatives</topic><topic>Fluocinonide - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Psoriasis - drug therapy</topic><topic>Random Allocation</topic><topic>Recurrence</topic><topic>Skin, nail, hair, dermoskeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GRATTAN, C.E.H.</creatorcontrib><creatorcontrib>CHRISTOPHER, A.P.</creatorcontrib><creatorcontrib>ROBINSON, M.</creatorcontrib><creatorcontrib>COWAN, M.A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GRATTAN, C.E.H.</au><au>CHRISTOPHER, A.P.</au><au>ROBINSON, M.</au><au>COWAN, M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Double-blind comparison of a dithranol and steroid mixture with a conventional dithranol regimen for chronic psoriasis</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1988-11</date><risdate>1988</risdate><volume>119</volume><issue>5</issue><spage>623</spage><epage>626</epage><pages>623-626</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>SUMMARY
Twenty four of 30 patients with chronic plaque psoriasis completed a double‐blind randomized paired comparison of dithranol in Lassar's paste versus dithranol and fluocinonide in Lassar's paste. There was a more rapid reduction in severity of the psoriasis on the side treated with the dithranol and fluocinonide mixture, but no difference in the final time to clearance between the two sides. There were fewer burning episodes on the side treated with dithranol and fluocinonide and greater staining of the skin. Of the 20 patients who were subsequently followed up for up to 3 months, 11 had relapsed more on the side treated with dithranol and fluocinonide, two on the side treated with dithranol alone and in seven there was no appreciable difference. It was concluded that the addition of a topical steroid to a conventional dithranol regimen produced more rapid initial clearance and less burning, but more rapid relapse of the psoriasis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3061441</pmid><doi>10.1111/j.1365-2133.1988.tb03473.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 1988-11, Vol.119 (5), p.623-626 |
| issn | 0007-0963 1365-2133 |
| language | eng |
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| subjects | Adolescent Adult Aged Anthralin - therapeutic use Biological and medical sciences Clinical Trials as Topic Double-Blind Method Drug Therapy, Combination Female Fluocinolone Acetonide - analogs & derivatives Fluocinonide - therapeutic use Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Psoriasis - drug therapy Random Allocation Recurrence Skin, nail, hair, dermoskeleton |
| title | Double-blind comparison of a dithranol and steroid mixture with a conventional dithranol regimen for chronic psoriasis |
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