Clinical pharmacokinetics of clozapine in chronic schizophrenic patients
The clinical pharmacokinetics of clozapine, an atypical neuroleptic, was evaluated in 10 chronic schizophrenic male patients after intravenous and oral administration. The mean equilibrium-state concentration ratio between blood and plasma was experimentally determined to be 0.87. The average values...
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| Veröffentlicht in: | European journal of clinical pharmacology 1988-01, Vol.34 (5), p.445-449 |
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| container_end_page | 449 |
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| container_issue | 5 |
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| container_title | European journal of clinical pharmacology |
| container_volume | 34 |
| creator | CHENG, Y. F LUNDBERG, T BONDESSON, U LINDSTRÖM, L GABRIELSSON, J |
| description | The clinical pharmacokinetics of clozapine, an atypical neuroleptic, was evaluated in 10 chronic schizophrenic male patients after intravenous and oral administration. The mean equilibrium-state concentration ratio between blood and plasma was experimentally determined to be 0.87. The average values for blood clearance, hepatic extraction ratio and oral bioavailability were 250 ml/min, 0.2 and 0.27, respectively. Plasma concentration peaked on average at 3 h. The mean volume of distribution at steady-state and the terminal half-life was 1.6 l/kg and 10.3 h, respectively. A large fraction of the dose is most probably metabolized by some extrahepatic presystemic routes. The large inter-individual variability in the bioavailability and clearance is probably the main reason for large variation in the steady-state plasma level in patients receiving the same oral dosage regimen. |
| doi_str_mv | 10.1007/BF01046700 |
| format | Article |
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The large inter-individual variability in the bioavailability and clearance is probably the main reason for large variation in the steady-state plasma level in patients receiving the same oral dosage regimen.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF01046700</identifier><identifier>PMID: 3203703</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Administration, Oral ; Adult ; Biological and medical sciences ; Chronic Disease ; Clozapine - administration & dosage ; Clozapine - pharmacokinetics ; Clozapine - therapeutic use ; Dibenzazepines - pharmacokinetics ; Humans ; Injections, Intravenous ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. 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F</creatorcontrib><creatorcontrib>LUNDBERG, T</creatorcontrib><creatorcontrib>BONDESSON, U</creatorcontrib><creatorcontrib>LINDSTRÖM, L</creatorcontrib><creatorcontrib>GABRIELSSON, J</creatorcontrib><title>Clinical pharmacokinetics of clozapine in chronic schizophrenic patients</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>The clinical pharmacokinetics of clozapine, an atypical neuroleptic, was evaluated in 10 chronic schizophrenic male patients after intravenous and oral administration. The mean equilibrium-state concentration ratio between blood and plasma was experimentally determined to be 0.87. The average values for blood clearance, hepatic extraction ratio and oral bioavailability were 250 ml/min, 0.2 and 0.27, respectively. Plasma concentration peaked on average at 3 h. The mean volume of distribution at steady-state and the terminal half-life was 1.6 l/kg and 10.3 h, respectively. A large fraction of the dose is most probably metabolized by some extrahepatic presystemic routes. The large inter-individual variability in the bioavailability and clearance is probably the main reason for large variation in the steady-state plasma level in patients receiving the same oral dosage regimen.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Clozapine - administration & dosage</subject><subject>Clozapine - pharmacokinetics</subject><subject>Clozapine - therapeutic use</subject><subject>Dibenzazepines - pharmacokinetics</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - metabolism</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUh4Moc04v3oUexINQfclLm_aowzlh4EXPJU1TGm2bmnQH99ebsTJPj9_7fTx4HyHXFB4ogHh8XgEFngqAEzKnHFkcIj0lcwCkcZoLOCcX3n8B0CQHnJEZMkABOCfrZWt6o2QbDY10nVT22_R6NMpHto5Ua3dyCIvI9JFqnA1o5FVjdnZonN6nQY5G96O_JGe1bL2-muaCfK5ePpbrePP--rZ82sQKKR3jSqoko1WWlDSvBWO8zijNZZnqKkWRpFIrrBhWVZmVdcIloETGBEs5l2XOFS7I3eHu4OzPVvux6IxXum1lr-3WFyJLch5eDuD9AVTOeu90XQzOdNL9FhSKvbbiX1uAb6ar27LT1RGdPIX-duqlD7JqJ3tl_BETGXKKCf4BHKN0Jw</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>CHENG, Y. F</creator><creator>LUNDBERG, T</creator><creator>BONDESSON, U</creator><creator>LINDSTRÖM, L</creator><creator>GABRIELSSON, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880101</creationdate><title>Clinical pharmacokinetics of clozapine in chronic schizophrenic patients</title><author>CHENG, Y. F ; LUNDBERG, T ; BONDESSON, U ; LINDSTRÖM, L ; GABRIELSSON, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-dac581d85b19f7224f8119ab6ed63756aec3d23ddb8bf54a03a32272644ab94c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Clozapine - administration & dosage</topic><topic>Clozapine - pharmacokinetics</topic><topic>Clozapine - therapeutic use</topic><topic>Dibenzazepines - pharmacokinetics</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHENG, Y. F</creatorcontrib><creatorcontrib>LUNDBERG, T</creatorcontrib><creatorcontrib>BONDESSON, U</creatorcontrib><creatorcontrib>LINDSTRÖM, L</creatorcontrib><creatorcontrib>GABRIELSSON, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHENG, Y. 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| ispartof | European journal of clinical pharmacology, 1988-01, Vol.34 (5), p.445-449 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Administration, Oral Adult Biological and medical sciences Chronic Disease Clozapine - administration & dosage Clozapine - pharmacokinetics Clozapine - therapeutic use Dibenzazepines - pharmacokinetics Humans Injections, Intravenous Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Schizophrenia - drug therapy Schizophrenia - metabolism |
| title | Clinical pharmacokinetics of clozapine in chronic schizophrenic patients |
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